Protease-activated receptor-1 (PAR-1) and regulation of Helicobacter pylori induced mucosal inflammation

蛋白酶激活受体-1 (PAR-1) 和幽门螺杆菌诱导的粘膜炎症的调节

• 批准号: nhmrc : 508963
• 负责人: A/Pr Richard Ferrero
• 金额: $ 31.88万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/protease-activated-receptor-mucosal-inflammation/100517
• 关键词: Protease; activated; receptor; PAR; regulation

Helicobacter pylori infections cause chronic gastritis which in some people results in stomach cancer or ulcers. We have identified a novel host factor, PAR-1, important for preventing this inflammation. We will use mice to identify how this molecule protects against gastritis and samples from patients to examine its importance in human disease. This will help explain why these diseases develop in some people but not others and perhaps allow identification of those at risk of developing disease.

幽门螺杆菌感染引起慢性胃炎，在某些人中导致胃癌或溃疡。我们已经确定了一种新的宿主因子，PAR-1，对预防这种炎症很重要。我们将使用小鼠来确定这种分子如何防止胃炎，并从患者身上提取样本来研究它在人类疾病中的重要性。这将有助于解释为什么这些疾病在某些人身上发生，而在另一些人身上却没有，也许还可以识别出那些有患病风险的人。