Epithelial cell signalling and host responses to virulent Helicobacter pylori strains.

上皮细胞信号传导和宿主对剧毒幽门螺杆菌菌株的反应。

• 批准号: nhmrc : 1011303
• 负责人: A/Pr Richard Ferrero
• 金额: $ 33.5万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/epithelial-cell-signalling-pylori-strains/109570
• 关键词: Epithelial; cell; signalling; host; responses

The stomach bacterium Helicobacter pylori causes various types of gastrointestinal disease. One of the questions that still perplexes researchers in the field, however, is why some infected individuals develop very severe forms of disease (ulcers or cancer) whilst others develop only inflammation. This project will investigate H. pylori interactions with cells that line the stomach wall and how these interactions may contribute to the development of more severe disease.

胃中的幽门螺杆菌会引起各种胃肠道疾病。然而，有一个问题仍然困扰着该领域的研究人员，那就是为什么一些被感染的人会发展成非常严重的疾病（溃疡或癌症），而另一些人只会发展成炎症。该项目将研究幽门螺杆菌与胃壁细胞的相互作用，以及这些相互作用如何导致更严重疾病的发展。