The Development of a Commercial Boron Neutron Capture Therapy Facility: establishing a clinically useable facility at Birmingham University

商业硼中子捕获治疗设施的开发：在伯明翰大学建立临床可用的设施

• 批准号: ST/I003169/1
• 负责人: David Parker
• 金额: $ 2.83万
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=ST%2FI003169%2F1
• 关键词: Development; Commercial; Boron; Neutron; Capture

Tumours in which the cancerous cells infiltrate the surrounding healthy tissue are particularly difficult to treat and currently have a rather poor prognosis. An example of such a type of cancer is a glio-blastoma multiforme (GBM), the most common form of primary, malignant brain tumour, which afflicts around 2000 people per year in the UK alone. Despite recent improvements in treatment, this essentially remains incurable. Boron Neutron Capture Therapy (BNCT), the subject of this project, is a form of cancer radiotherapy and looks particularly well-suited to treating this type of tumour. In this, an isotope of boron, boron-10, is administered to the patient in such a way that it accumulates in the cancerous cells. Boron-10 is stable and harmless, until it reacts with thermal neutrons. The products of this reaction destroy the cancerous cells in which they are created. The treatment then proceeds by passing a beam of neutrons though the tumour once the boron-10 has accumulated, thereby destroying most of the cancer cells. The remainder can be treated with standard radiotherapy. Recent studies of this therapy in Japan have shown very promising results. The aim of this project is to create a technology driver for a BNCT facility in Birmingham University and the Queen Elizabeth Hospital in Birmingham. This will be done in two phases: the first determining the changes required to an existing facility to deliver this and the second implementing them. Once complete, this will be used to undertake clinical trials of the therapy to demonstrate its effectiveness for a number of types of cancer. At a later stage, this driver will also be used to design a BNCT facility that can be constructed commercially and used in other large radiotherapy departments in the UK and elsewhere.

其中癌细胞浸润周围健康组织的肿瘤特别难以治疗，并且目前具有相当差的预后。这种类型的癌症的一个例子是多形性胶质母细胞瘤（GBM），这是原发性恶性脑肿瘤的最常见形式，仅在英国每年就有大约2000人受到影响。尽管最近在治疗方面有所改进，但这基本上仍然是无法治愈的。硼中子捕获疗法（BNCT）是该项目的主题，是癌症放射疗法的一种形式，看起来特别适合治疗这种类型的肿瘤。在这种情况下，硼的同位素硼-10以这种方式给予患者，使其在癌细胞中积累。硼-10在与热中子反应之前是稳定且无害的。这种反应的产物会破坏产生它们的癌细胞。一旦硼-10积累起来，治疗就通过使中子束穿过肿瘤来进行，从而摧毁大部分癌细胞。其余的可以用标准放射治疗。最近在日本对这种疗法的研究显示出非常有希望的结果。该项目的目的是为伯明翰大学和伯明翰伊丽莎白女王医院的BNCT设施创建一个技术驱动程序。这项工作将分两个阶段进行：第一阶段确定为实现这一目标对现有设施所需的改变，第二阶段实施这些改变。一旦完成，这将用于进行临床试验的治疗，以证明其有效性的一些类型的癌症。在稍后阶段，该驱动程序还将用于设计BNCT设施，该设施可以商业化建造并用于英国和其他地方的其他大型放射治疗部门。