STABILIZED IMAGING FOR THE SCANNING LASER OPHTHALMOSCOPE

第二阶段研究的总体目标是构建和记录新一代视网膜成像系统的设计，该系统将第一阶段中展示的视网膜跟踪（RT）技术整合到先进的扫描激光检眼镜（SLO）中，并展示该系统的临床价值。RT技术可以在正常眼球运动的情况下实现连续、清晰、稳定的SLO图像采集和图像平均。预期临床试验将提供显示RT稳定的SLO成像（或TSLO）对于诊断和治疗过程以及对于研究应用的价值的数据。这些数据，当公开传播，预计将提高认识，在眼科社区的TSLO的价值，从而提高其市场潜力。广泛的数据、有效的临床系统和工程文档的结合将为将该技术转移到商业制造商提供坚实的基础。与第一阶段不同，第二阶段建造的RT系统将适合临床使用，并将改进其跟踪速度，精度和范围，同时简化其控制。它将在临床和研究应用中进行测试，范围从简单的检眼镜检查到先进的诊断程序，如血管造影和视野检查。所获得的数据将在技术会议上发表和介绍。拟定商业应用：这项研究的成功结果将导致新的，更强大的诊断系统，用于早期检测和诊断视网膜疾病和其他视觉障碍。该方法将提高激光扫描成像系统及相关设备的实用性和商业价值。改进血管造影术将可能使用更少的染料和更低的风险。治疗程序也可以受益于精确的稳定。预计在本研究期间开发的技术将被纳入向眼科医生商业销售的一种或多种产品中。

The overall objectives of this Phase II research are to build and document the design of a new generation retinal imaging system incorporating the Retinal Tracking (RT) technology demonstrated in Phase I into an advanced Scanning 1aaser Ophthalmoscope (SLO), and to demonstrate the clinical value of that system. The RT technology enables continuous, well- defined, stable SLO image acquisition and image averaging despite normal eye motions. it is anticipated that the clinical tests will provide data showing the value of RT-stabilized SLO imaging (or TSLO) for diagnostic and therapeutic procedures, as well as for research applications. These data, when publicly disseminated, are expected to increase awareness within the ophthalmologic community of the TSLO's value, thereby enhancing its market potential. The combination of extensive data, a working clinical system, and engineering documentation, will provide a solid foundation for transferring the technology to a commercial manufacturer. Unlike Phase I, the RT system to be built in Phase II will be suitable for clinical use, incorporating improvements to enhance its tracking speed, precision and range while simplifying its control. it will be tested in clinical and research applications ranging from simple ophthalmoscopic exams to advanced diagnostic procedures such as angiography and perimetry. Data acquired will be published and presented at technical conferences. PROPOSED COMMERCIAL APPLICATION: The successful outcome of the proposed research will lead to new, more powerful diagnostic systems for the early detection and diagnosis of retinal disease and other visual disorders. The proposed approach will increase the applicability and commercial value of the scanning laser imaging systems and related devices. Improved angiography will be possible with less dye and lower risk. Therapeutic procedures may also benefit from precise stabilization. It is anticipated that the technology developed during this research will be incorporated into one or more products sold commercially to ophthalmologists.