Retinal Tracking for Enhances OCT Imaging

视网膜跟踪增强 OCT 成像

• 批准号: 6743962
• 负责人: R DANIEL FERGUSON
• 金额: $ 31.91万
• 依托单位: PHYSICAL SCIENCES, INC
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6743962
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; clinical biomedical equipment; clinical research; eye disorder diagnosis; eye movements; human subject; image processing; morphometry; optical tomography; optics; retina; retinography; visual tracking

DESCRIPTION (provided by applicant): Physical Sciences Inc. (PSI), with support from Carl Zeiss Ophthalmic Systems (CZOS), has successfully completed a Phase I research program demonstrating the feasibility of combining Optical Coherence Tomography (OCT) and patented PSI retinal tracking technology. A Phase II research and development program is proposed to create Tracking OCT (TOCT) instrumentation that will significantly enhance retinal imaging and morphometric diagnostics. The capability to reproducibly map three-dimensional structures in the living eye, approaching cellular resolution, will lead to improved understanding of disease processes and improved sensitivity and specificity of diagnostic procedures. At present, the slow speed of 2-D OCT imaging limits diagnostic potential in the clinic. Normal eye movement often renders transverse OCT scan registration difficult to correct, creating image errors and artifacts. PSI's retinal tracking technology is a highspeed, non-imaging system that uses retinal landmarks to achieve precise transverse image registration, and with tracking errors smaller than the OCT beam diameter. Precisely aligned scans can be compared months, or years apart. Frame averaging techniques can reduce OCT speckle noise without loss of transverse or longitudinal resolution. Adjacent 2-D scans can be concatenated into 3-D data sets. Standard resolution and high resolution TOCT systems will be assembled and tested in clinical studies at New England Eye Center.

描述（由申请人提供）：Physical Sciences Inc. (PSI)在Carl Zeiss Ophthalmic Systems（CZOS）的支持下，成功完成了第一阶段研究计划，证明了光学相干断层扫描（OCT）和专利PSI视网膜跟踪技术相结合的可行性。第二阶段的研究和开发计划，提出创建跟踪OCT（TOCT）仪器，将显着提高视网膜成像和形态诊断。在活体眼睛中可再现地绘制三维结构的能力，接近细胞分辨率，将导致对疾病过程的更好理解以及诊断程序的更高灵敏度和特异性。目前，2-D OCT成像速度慢限制了临床诊断潜力。正常的眼睛运动通常使得横向OCT扫描配准难以校正，从而产生图像误差和伪影。PSI的视网膜跟踪技术是一种高速、非成像系统，使用视网膜标志实现精确的横向图像配准，跟踪误差小于OCT光束直径。精确对齐的扫描可以相隔数月或数年进行比较。帧平均技术可以在不损失横向或纵向分辨率的情况下减少OCT散斑噪声。相邻的2-D扫描可以连接成3-D数据集。标准分辨率和高分辨率TOCT系统将在新英格兰眼科中心组装并在临床研究中进行测试。