Advanced Laser Source for High-speed Adaptive Optics OCT

用于高速自适应光学 OCT 的先进激光源

• 批准号: 8058255
• 负责人: R DANIEL FERGUSON
• 金额: $ 21.51万
• 依托单位: PHYSICAL SCIENCES, INC
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8058255
• 关键词: Algorithms; Area; Blindness; Caliber; Characteristics; Choroid; Clinical; Custom; Development; Devices; Diagnosis; Dimensions; Disease; Engineering; Eye; Eye diseases; Generations; Human; Image; Lasers; Lateral; Life; Light; Maps; Methods; Monitor; Morphologic artifacts; Motion; Ophthalmoscopy; Optical Coherence Tomography; Pattern; Performance; Phase; Photoreceptors; Population; Positioning Attribute; Process; Real-Time Systems; Relative (related person); Research; Research Personnel; Resolution; Retinal; Retinal Cone; Retinal Diseases; Sapphire; Scanning; Scientist; Source; Speed; Supervision; System; Technology; Testing; Time; Work; adaptive optics; base; clinical application; computerized data processing; cost; design; human subject; image processing; instrument; macula; millisecond; novel; optical imaging; physical science; programs; three dimensional structure; tool; volunteer

DESCRIPTION (provided by applicant): Physical Sciences Inc. (PSI) proposes to develop a new adaptive optics imaging approach to high- speed 3D-retinal mapping with enhanced Fourier Domain Mode-locked (FDML) swept-source technology. PSI is currently engaged in ongoing development of high performance, high resolution multimodal adaptive optics (AO) retinal imagers. Such systems resolve and quantify cone photoreceptors across the macula, image and delineate retinal layers, reveal and map microvasculature, and image deep in the choroid, These multimodal AO systems integrate scanning laser ophthalmoscopy (AOSLO) , wide-field field imaging, retinal tracking, and, to our knowledge, are the first multimodal systems to incoprporate 1-5m swept source-based Fourier domain optical coherence tomography (AO-SSOCT) suitable for use in a broad clinical population for investigating structural and functional detail. However, in the living, fixating eye, even the smallest motions are magnified relative to the small dimensions of typical AO scan (~1 to 3 deg). At present, with existing spectral domain or swept-source technology, even high-resolution AO-OCT B-scan rates approaching 300/s (~ten times video rate @ >500 A-lines per scan) remain too slow to reliably capture the local 3D structure of particular layers, whose lateral motions can be as much as few cone diameters in the inter-line interval of several milliseconds. These scans must reach a speed sufficient to adequately cross-correlate AO-OCT cone images with AOSLO cone mosaics to derive the true multimodal advantage. The recent development of Fourier domain mode-locked [FDML] swept-source laser technology by researchers at MIT has enabled the OCT A-line rate to reach 370kline/s, and beyond. Thus, the resulting accessible B-scan rates at high resolution approach a threshold (> 1000/s) where motion artifacts from the human eye do not irretrievably disrupt the local cone pattern, which is the best basis for image correction, alignment and mosaic generation over clinically useful retinal areas and volumes. To achieve these capabilities, progress on both practical multimodal AO systems and FDML or equivalent swept-source technologies is needed. PSI and its subsidiary Q-Peak are well positioned to move on both fronts together. In addition, PSI is actively engaged in the development of customized Graphical Processing Unit (GPU) algorithms and systems for real time, high-speed image cube processing that can be applied to AO-OCT. PUBLIC HEALTH RELEVANCE: The advent of high speed, high resolution ocular imaging has opened new avenues of research into the understanding and treatment of eye disease and vision loss. The proposed high performance AO instrument with high speed swept source laser technology will allow powerful new adaptive optics technology to be used by greater numbers of clinicians and scientists. These researchers will, in turn, find novel and important uses for this new tool in clinical application for detecting disease and monitoring treatment.

描述（由申请人提供）： 物理科学公司(PSI)提出了一种新的自适应光学成像方法，利用增强的傅立叶域锁模（FDML）扫频光源技术实现高速3D视网膜映射。PSI目前正在开发高性能、高分辨率的多模式自适应光学（AO）视网膜成像仪。这种系统解析和量化跨越黄斑的视锥光感受器，成像和描绘视网膜层，揭示和映射微血管系统，并在脉络膜深处成像。这些多模式AO系统集成了扫描激光检眼镜检查（AOSLO）、宽视场成像、视网膜跟踪，并且据我们所知，是第一个多模态系统，包括1- 5米扫频源为基础的傅立叶域光学相干层析成像（AO-SSOCT）适用于广泛的临床人群，用于研究结构和功能细节。然而，在活的、注视的眼睛中，即使是最小的运动也相对于典型AO扫描的小尺寸（~1至3度）被放大。目前，利用现有的谱域或扫频源技术，即使接近300/s的高分辨率AO-OCT B扫描速率（约为视频速率的十倍，@ >500条A线/扫描）仍然太慢而不能可靠地捕获特定层的局部3D结构，其横向运动在几毫秒的线间间隔中可以是几个圆锥直径。这些扫描必须达到足以充分交叉关联AO-OCT锥图像与AOSLO锥镶嵌的速度，以获得真正的多模态优势。麻省理工学院的研究人员最近开发的傅里叶域锁模[FDML]扫频光源激光技术使OCT A线速率达到370 kline/s，甚至更高。因此，在高分辨率下得到的可访问B扫描速率接近阈值（> 1000/s），其中来自人眼的运动伪影不会不可逆转地破坏局部视锥图案，这是在临床上有用的视网膜区域和体积上进行图像校正、对准和马赛克生成的最佳基础。为了实现这些能力，需要在实用的多模态AO系统和FDML或等效扫频源技术方面取得进展。PSI及其子公司Q-Peak在这两个方面都处于有利地位。此外，PSI还积极参与开发定制的图形处理单元（GPU）算法和系统，用于可应用于AO-OCT的真实的实时、高速图像立方体处理。 公共卫生相关性： 高速、高分辨率眼部成像的出现为理解和治疗眼部疾病和视力丧失开辟了新的研究途径。所提出的具有高速扫频光源激光技术的高性能AO仪器将允许更多的临床医生和科学家使用强大的新自适应光学技术。反过来，这些研究人员将发现这种新工具在临床应用中用于检测疾病和监测治疗的新的重要用途。