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A novel role for Alzheimer tau protein in insulin secretion and type 2 diabetes

A novel role for Alzheimer tau protein in insulin secretion and type 2 diabetes
阿尔茨海默氏tau蛋白在胰岛素分泌和2型糖尿病中的新作用
批准号:
nhmrc : 1125379
负责人:
A/Pr Sofianos Andrikopoulos
金额:
$69.89万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2017
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2017-01-01 至 2020-12-31

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中文摘要
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英文摘要
There is a strong association between type 2 diabetes and Alzheimer's disease, however the reason for this is not known. In Azheimer's disease a protein called tau does not function normally and contributes to the declining cognitive function. We have shown that when tau is absent, this lowers blood glucose and reduces the hallmark defects that contribute to type 2 diabetes. By understanding how tau works we may be able to provide better therapeutic agents to treat type 2 diabetes.
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A novel role for Alzheimer tau protein in insulin secretion and type 2 diabetes
  • 批准号:
    nhmrc : GNT1125379
  • 项目类别:
    Project Grants
  • 资助金额:
    $102.37万
  • 财政年份:
    2017
  • 负责人:
    A/Pr Sofianos Andrikopoulos
  • 依托单位:
Role of UBL-5 in mitochondrial function and glucose metabolism
  • 批准号:
    nhmrc : 1069374
  • 项目类别:
    Project Grants
  • 资助金额:
    $43.18万
  • 财政年份:
    2014
  • 负责人:
    A/Pr Sofianos Andrikopoulos
  • 依托单位:
Investigating the novel role of SEPS1 in the prevention of islet beta cell failure and diabetes
  • 批准号:
    nhmrc : 1025755
  • 项目类别:
    Project Grants
  • 资助金额:
    $35.73万
  • 财政年份:
    2012
  • 负责人:
    A/Pr Sofianos Andrikopoulos
  • 依托单位:
Unravelling the mechanisms by which insulin hypersecretion is detrimental to ß-cell function and survival in Type 2 diabetes
  • 批准号:
    nhmrc : 1002902
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $48.53万
  • 财政年份:
    2011
  • 负责人:
    A/Pr Sofianos Andrikopoulos
  • 依托单位:
国内基金
海外基金
PfAP2-R介导的PfCRT转录调控在恶性疟原虫对喹啉类药物抗性中的作用及机制研究
Sestrin2抑制内质网应激对早产儿视网膜病变的调控作用及其机制研究
  • 批准号:
    82371070
  • 项目类别:
    面上项目
  • 资助金额:
    49.00万元
  • 批准年份:
    2023
  • 负责人:
    赵培泉
  • 依托单位: