Mechanisms of Insulin Resistance and Diabetes Susceptibility

胰岛素抵抗和糖尿病易感性的机制

• 批准号: nhmrc : 513834
• 负责人: A/Pr Sofianos Andrikopoulos
• 金额: $ 42.26万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-insulin-resistance-diabetes-susceptibility/99740
• 关键词: Mechanisms; Insulin; Resistance; Diabetes; Susceptibility

The two main forms of diabetes - types 1 (T1D) and 2 (T2D) - pose a major problem. It is difficult to identify what causes diabetes. Recently, people at risk of T1D were found to have insulin resistance, a condition thought typical only of T2D. Excitingly, we discovered that the best T1D animal model also shows insulin resistance, and we used it to map important genes. We will now identify these genes. This will help us understand the disease process and to develop better treatments for it.

糖尿病的两种主要形式-1型（T1 D）和2型（T2 D）-构成了一个主要问题。很难确定是什么导致糖尿病。最近，人们发现有T1 D风险的人有胰岛素抵抗，这种情况被认为是典型的T2 D。令人兴奋的是，我们发现最好的T1 D动物模型也显示出胰岛素抵抗，我们用它来绘制重要基因。现在我们将识别这些基因。这将有助于我们了解疾病的过程，并为它开发更好的治疗方法。