Understanding the cause and consequence of impaired insulin secretion in the NZO mouse a model of diabetes.

了解糖尿病模型 NZO 小鼠胰岛素分泌受损的原因和后果。

• 批准号: nhmrc : 509300
• 负责人: A/Pr Sofianos Andrikopoulos
• 金额: $ 47.42万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-cause-consequence-model-diabetes/76353
• 关键词: Understanding; cause; consequence; impaired; insulin

Type 2 diabetes is a major health problem affeting over 1 million Australians. A key feature of this disease is reduced secretion of the pancreratic hormone insulin which results in high blood sugar levels. We are using a naturally occurring animal model of diates called the NZO mouse to understand why the pancreas secretes less insulin and the consequences of this defect. This project has the potential of providing better therapeutic strategies for patients with Type 2 diabetes.

2 型糖尿病是影响超过 100 万澳大利亚人的主要健康问题。这种疾病的一个关键特征是胰腺激素胰岛素的分泌减少，从而导致高血糖。我们正在使用一种称为 NZO 小鼠的天然二甲动物模型来了解为什么胰腺分泌的胰岛素较少以及这种缺陷的后果。该项目有潜力为 2 型糖尿病患者提供更好的治疗策略。