Unravelling the mechanisms by which insulin hypersecretion is detrimental to ß-cell function and survival in Type 2 diabetes
Unravelling the mechanisms by which insulin hypersecretion is detrimental to ß-cell function and survival in Type 2 diabetes
批准号:
nhmrc : 1002902
负责人:
A/Pr Sofianos Andrikopoulos
金额:
$48.53万
依托单位国家:
澳大利亚
项目类别:
Research Fellowships
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2016-12-31
中文摘要
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英文摘要
Type 2 diabetes is associated with reduced levels of the hormone insulin that results in an increase in blood sugar. Evidence suggests that when the cells that make insulin are overworked they fail to produce the right amount of this hormone to keep blood sugar levels normal. In this proposal we will determine how overworking the insulin producing cells damages them and assess whether reducing the need to overwork is beneficial and thus lead to reduced blood sugar levels in Type 2 diabetes.
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