Unravelling the mechanisms by which insulin hypersecretion is detrimental to ß-cell function and survival in Type 2 diabetes

揭示胰岛素分泌过多对 2 型糖尿病患者的细胞功能和生存有害的机制

• 批准号: nhmrc : 1002902
• 负责人: A/Pr Sofianos Andrikopoulos
• 金额: $ 48.53万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/unravelling-mechanisms-insulin-2-diabetes/108874
• 关键词: Unravelling; mechanisms; insulin; hypersecretion; detrimental

Type 2 diabetes is associated with reduced levels of the hormone insulin that results in an increase in blood sugar. Evidence suggests that when the cells that make insulin are overworked they fail to produce the right amount of this hormone to keep blood sugar levels normal. In this proposal we will determine how overworking the insulin producing cells damages them and assess whether reducing the need to overwork is beneficial and thus lead to reduced blood sugar levels in Type 2 diabetes.

2型糖尿病与导致血糖升高的激素胰岛素水平降低有关。有证据表明，当制造胰岛素的细胞过度工作时，它们无法产生适量的这种激素来保持血糖水平正常。在这项提案中，我们将确定过度工作如何损害胰岛素产生细胞，并评估减少过度工作的需要是否有益，从而导致2型糖尿病血糖水平降低。