The role of insulin hypersecretion in beta cell dysfunction in Type 2 diabetes

胰岛素分泌过多在 2 型糖尿病 β 细胞功能障碍中的作用

• 批准号: nhmrc : 566826
• 负责人: A/Pr Sofianos Andrikopoulos
• 金额: $ 21.25万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-insulin-hypersecretion-2-diabetes/116017
• 关键词: role; insulin; hypersecretion; beta; cell

The treatment of diabetes involves the use of drugs that stimulate the release of insulin from the pancreas to reduce the high blood sugar levels. However, we believe that while in the short term this is a good strategy, in the long-term it damages the cells that produce insulin leading to a worsening state of diabetes. It is the aim of this application to understand the mechanisms by which the insulin producing cells are damaged when forced to oversecrete insulin.

糖尿病的治疗包括使用刺激胰腺释放胰岛素的药物来降低高血糖水平。然而，我们相信，虽然在短期内这是一个很好的策略，但从长期来看，它会损害产生胰岛素的细胞，导致糖尿病的恶化。该应用程序的目的是了解胰岛素产生细胞在被迫过量分泌胰岛素时受损的机制。