Investigating the novel role of SEPS1 in the prevention of islet beta cell failure and diabetes

研究 SEPS1 在预防胰岛 β 细胞衰竭和糖尿病中的新作用

• 批准号: nhmrc : 1025755
• 负责人: A/Pr Sofianos Andrikopoulos
• 金额: $ 35.73万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-novel-role-failure-diabetes/110450
• 关键词: Investigating; novel; role; SEPS1; prevention

SEPS1 is an important glucose-regulated protein whose function is to protect tissues from oxidative stress. Inhibition of SEPS1 by hyperglycaemia, is a mechanism for progression of Type 1 and Type 2 diabetes once hyperglycaemia supervenes. The overall aim of the project is to investigate the function of the novel SEPS1, using transgenic and knockout approaches.

SEPS1是一种重要的葡萄糖调节蛋白，其功能是保护组织免受氧化应激。高血糖对SEPS1的抑制是一旦发生高血糖，1型和2型糖尿病进展的机制。该项目的总体目标是使用转基因和敲除方法研究新型SEPS1的功能。