The role of liver Fructose-1,6-phosphatase (FBPase) in body weight regulation

肝脏果糖 1,6 磷酸酶 (FBPase) 在体重调节中的作用

• 批准号: nhmrc : 566784
• 负责人: A/Pr Sofianos Andrikopoulos
• 金额: $ 32.99万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-liver-fructose-weight-regulation/82276
• 关键词: role; liver; Fructose; phosphatase; FBPase

We have shown that fructose-1,6-bisphosphatase (FBPase), an enzyme important in producing sugar from the liver and one that is connected to Type 2 diabetes, does not cause an increase in sugar production when there is more of the enzyme in mouse livers. It does, however, lower both body weight and the amount of food the mice consume. We therefore hypothesise that liver FBPase is important in controlling body weight in humans and our project aims to find out exactly how and why this happens.

我们已经证明，果糖-1，6-二磷酸酶（FBPase）是一种重要的酶，在从肝脏产生糖和一个与2型糖尿病，不引起糖的产量增加时，有更多的酶在小鼠肝脏。然而，它确实降低了小鼠的体重和食物消耗量。因此，我们假设肝脏FBPase在控制人类体重方面很重要，我们的项目旨在找出这种情况是如何发生的以及为什么会发生。