EPIDEMIOLOGIC STUDIES OF DIET AND CANCER IN HAWAII

申请人的描述（applicant's description） 本次竞争性更新的资助号为P01 CA 33619 "流行病学研究， 夏威夷的饮食与癌症"继续探索癌症的病因 以及癌症发病率种族差异的原因。 过去的周期 格兰特在很大程度上依赖于病例对照研究， 探讨饮食与肺、结直肠、子宫内膜、甲状腺 胃癌、膀胱癌、皮肤癌和其他癌症。 此外，我们还进行了几次 饮食方法学研究。 在这个周期中，我们建议利用 最近在夏威夷发起了一个多种族的群体， 血液和尿液标本的生物储存库，并使用此资源进行测试 与生物标记物和选定的癌症部位有关的几种假设。 在四年的时间内，将从队列中收集生物样本 日本人、高加索人和夏威夷土著民族的参与者 奥廷加岛，利用当地诊所广泛分布的设施， 实验室 基于62%的预期总体响应率，我们 将从18，535名男性和20，452名女性身上采集样本。 另外还有按 将进行校准子研究，以使我们能够调整测量 生物标志物的错误。 生物标本将以多份等分试样储存so 在-150 ℃（血液）和-80 ℃（尿液）下。 结肠直肠、肺、 参与者中的乳腺癌和前列腺癌将通过 夏威夷肿瘤登记处的快速报告。 血液和尿液的标记 将检查的包括：1）维生素D代谢产物，叶酸和同型半胱氨酸， 异硫氰酸酯，胰岛素和葡萄糖，胰岛素样生长因子，和 与结肠直肠癌相关的选定遗传标记; 2）类胡萝卜素， 生育酚、维生素C、总酚、异硫氰酸酯、硒， 异前列烷与肺癌的关系; 3）植物雌激素，类胡萝卜素， 生育酚、胰岛素样生长因子、雌激素和雄激素， 与乳腺癌的关系;以及4）硒，植物雌激素，类胡萝卜素， 生育酚、脂肪酸、胰岛素样生长因子、异前列腺素和 雄激素与前列腺癌的关系。所有四个项目都将使用嵌套的 病例对照设计，并将由四个核心组成部分支持：1） 管理，2）数据采集，3）生物标本，4）数据管理 和分析 通过利用夏威夷的独特资源，即， 多民族队列研究，该项目将有助于解决某些及时 与癌症的营养病因学有关的问题。

DESCRIPTION (Applicant's Description) This competing renewal of grant No. P01 CA 33619 "Epidemiologic Studies of Diet and Cancer in Hawaii" continues to explore etiologic factors for cancer and reasons for ethnic variations in cancer incidence. Past cycles of the grant relied heavily, though not exclusively, on case-control studies to explore the relationship of diet to lung, colorectal, endometrial, thyroid, gastric, bladder, skin and other cancers. In addition, we conducted several dietary methodology studies. For this cycle, we propose to take advantage of a recently initiated multi-ethnic cohort in Hawaii to establish a biorepository of blood and urine specimens, and to use this resource to test several hypotheses related to biological markers and selected cancer sites. Over a period of four years, biological samples will be collected from cohort participants of Japanese, Caucasian and Native Hawaiian ethnicity on the island of Oahu, utilizing the widely dispersed facilities of a local clinical laboratory. Based on an anticipated overall response rate of 62 percent, we will obtain samples from 18,535 males and 20,452 females. In addition, a calibration substudy will be conducted to enable us to adjust for measurement error in the biomarkers. The biospecimens will be stored in multiple aliquotso at -150 C (blood) and -80C (urine). Incident cases of colorectal, lung, breast and prostate cancer among the participants will be identified through rapid reporting by the Hawaii Tumor Registry. Blood and urinary markers that will be examined include: 1) vitamin D metabolites, folate and homocysteine, isothiocyanates, insulin and glucose, insulin-like growth factors, and selected genetic markers in relation to colorectal cancer; 2) carotenoids, tocopherols, vitamin C, total phenol, isothiocyanates, selenium, and isoprostane in relation to lung cancer; 3) phytoestrogens, carotenoids, tocopoherols, insulin-like growth factors, estrogens, and androgens in relation to breast cancer; and 4) selenium, phytoestrogens, carotenoids, tocopoherols, fatty acids, insulin-like growth factors, isoprostane, and androgens in relation to prostate cancer. All four projects will use a nested case-control design and will be supported by four Core Components: 1) Administration, 2) Data Collection, 3) Biospecimens, and 4) Data Management and Analysis. By taking advantage of a unique resource in Hawaii, namely, the Multi-ethnic Cohort Study, this project will help address certain timely issues related to the nutritional etiology of cancer.