CHROMOSOME METABOLISM AND CANCER

染色体代谢与癌症

• 批准号: 6512340
• 负责人: MENG-CHAO H YAO
• 金额: $ 27.95万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6512340
• 关键词: CHROMOSOME; METABOLISM; CANCER

DESCRIPTION: (provided by Applicant) This renewal application is seeking support for a program that trains researchers to understand the links between chromosome metabolism and cancer. Recent advances in the studies of genes and genomes have greatly facilitated the understanding of chromosome metabolism and illustrated its importance in cancer cell formation and progression. The 27 training faculty are experts in this area from the Basic Sciences Division and the Human Biology Division of Fred Hutchinson Cancer Research Center. Many are leading scientists in their own fields, and together they form a cohesive group that approaches the issue from different but complementing angles. They include structural biologists in addition to molecular and cellular biologists, and utilize various model organisms such as nematode, fly, yeast in addition to vertebrates and cultured cells in their studies. The breadth and depth of this program should help generate excellent young scientists ready to deal with this complex problem. The program will continue to train at the predoctoral and postdoctoral levels. Three predoctoral positions are requested to maintain the current level of support of this successful program that was initiated five years ago following the formation of the Molecular and Cell Biology (MCB) Graduate Program. The postdoctoral positions will be expanded to six (from the current four positions) due to increased interests in this area and the expanded training faculty of the program (from 14 to 27). Predoctoral trainees will be recruited among the MCB students, who enter the joint program with the University of Washington, through vigorous competition and are among the best in the nation. Postdoctoral trainees will be recruited nationally. Training of predoctoral students includes course work, laboratory rotations and thesis research. Postdoctoral training will focus on independent research. All t r ainees will benefit from the rich activities available for cancer researchers at this Center. They will participate in weekly research group meetings, joint group meetings and Division meetings to report research findings to and exchange ideas with scientists within the lab, labs with similar interests, or the entire Divisions. They will also benefit from the strong interdisciplinary programs in the Center that expose basic scientists to clinical and public health aspects of cancer. In addition, they will have ready access to the newly formed patient care unit on campus. It is hoped that this program will train young scientists with in-depth understanding of chromosome metabolism and able to explore its various links to cancer cause, care and prevention.

描述：(申请人提供)此续签申请正在寻求 支持一项培训研究人员了解 染色体代谢与癌症。基因和分子生物学研究的最新进展 基因组极大地促进了对染色体新陈代谢的了解 并说明了它在癌细胞形成和发展中的重要性。这个 27名培训人员是基础科学处的这一领域的专家 和弗雷德·哈钦森癌症研究中心的人类生物部。 许多人都是各自领域的顶尖科学家，他们共同组成了一个 从不同但互补的角度处理问题的有凝聚力的团队 天使。他们包括结构生物学家，除了分子和 细胞生物学家，并利用各种模式生物，如线虫， 苍蝇、酵母菌以及脊椎动物的培养细胞都在研究中。 这个项目的广度和深度应该有助于培养优秀的年轻人 科学家们准备好处理这个复杂的问题。 该项目将继续进行博士后和博士后培训。 需要3个博士前职位，以维持目前的 支持这一成功的计划，该计划是在五年前启动的 分子与细胞生物学(MCB)研究生课程的形成。这个 博士后职位将从目前的四个增加到六个 职位)，原因是对这一领域的兴趣增加和培训范围扩大 该项目的教职员工(从14岁到27岁)。博士前实习生将被 从MCB学生中招募，这些学生与 华盛顿大学，通过激烈的竞争，名列前茅 在全国范围内。博士后实习生将在全国范围内招聘。培训 博士前学习包括课程作业、实验室轮换和论文 研究。博士后培训将侧重于独立研究。全 癌症患者将从丰富的癌症活动中受益 该中心的研究人员。他们将参加每周一次的研究小组 会议、联合小组会议和分部会议以报告研究 向实验室内的科学家提供发现并与他们交流想法，实验室和 相似的利益，或者整个分歧。他们还将受益于 该中心强大的跨学科项目让基础科学家 癌症的临床和公共卫生方面。此外，他们将拥有 随时可以进入校园内新成立的病人护理病房。希望是这样的 这个项目将培养年轻的科学家，对 染色体新陈代谢并能够探索其与癌症原因的各种联系， 护理和预防。