MOUSE MODELS OF CANCER, BONE DISEASE, AND LACTATION

癌症、骨病和哺乳期小鼠模型

• 批准号: 6530030
• 负责人: THOMAS J ROSOL
• 金额: $ 10.93万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6530030
• 关键词: biological models; bone metabolism; bone neoplasms; disease /disorder model; estrogen receptors; hypercalcemia; laboratory mouse; lactation; lymphoma; metastasis; model design /development; parathyroid hormone related protein

DESCRIPTION (Adapted from the applicant's abstract): The K26 Award will be utilized to devote 50% effort to research in mouse pathobiology and to mentoring veterinarians and PhD graduate students in Veterinary Biosciences and other graduate programs at OSU in experimental pathophysiology of mouse models of human disease. There will be four major research projects: 1) develop a mammary gland-specific 'knock-out' model to investigate the function of parathyroid hormone-related protein (PTHrP) during lactation and in the neonate during suckling (ongoing project); 2) investigate the pathogenesis of humoral hypercalcemia of malignancy in a new SCID/beige mouse model of human HTLV-1-associated lymphoma (ongoing project); 3) investigate the pathogenesis of bone formation induced by bone metastases of human prostate cancer ("osteoblastic" metastases) by xenotransplantation of prostate epithelial cells in bones of athymic mice (new project); and 4) examine the effects of disruption (knock-out) of the genes for estrogen receptor alpha and beta on bone remodeling in normal, ovariectomized, and estrogen-treated mice (new collaborative project). The models have been carefully chosen and developed to mimic human disease and to provide unique opportunities to gain knowledge and train mouse pathobiologists in areas that are poorly understood, namely bone disease, cancer in bone, osteoporosis, and humoral hypercalcemia of malignancy. The projects will build on the long-term expertise of the applicant's laboratory in the pathophysiology of bone, cancer, and hypercalcemia in mice. Mentorship will consist of: 1) serving as advisor for veterinarians pursuing a PhD in experimental mouse pathobiology (currently advisor for five DVMs); 2) serving as collaborative mentor on research projects by veterinarians and basic scientist PhD candidates in the Department of Veterinary Biosciences (currently 17 projects) and PhD candidates in the Molecular, Cellular, and Developmental Biology Program and Comprehensive Cancer Center at OSU; 3) participating in training programs offered by the Transgenic Animal Shared Resource; 4) collaborating on research projects involving experimental pathobiology of mice; and 5) developing a training program in mouse pathobiology.

描述（改编自申请人的摘要）：K26奖将是 用于将50%的精力用于小鼠病理学研究， 指导兽医和兽医生物科学博士研究生 和其他研究生课程在俄勒冈州立大学的实验病理生理学的小鼠 人类疾病的模型。 将有四个主要研究项目：1） 开发乳腺特异性"基因敲除"模型以研究 甲状旁腺相关蛋白（PTHrP）在哺乳期和 新生儿在哺乳期（正在进行的项目）; 2）调查的发病机制 一种新SCID/Beige小鼠恶性肿瘤模型中体液性高钙血症 HTLV-1相关淋巴瘤（正在进行的项目）; 3）研究发病机制 人前列腺癌骨转移诱导骨形成 （"成骨细胞"转移）通过异种移植前列腺上皮细胞 无胸腺小鼠骨骼中的细胞（新项目）;以及4）检查 雌激素受体α和β基因的破坏（敲除） 骨重建正常，卵巢切除，雌激素治疗的小鼠（新 合作项目）。 这些模型是经过精心挑选和开发的 来模拟人类的疾病，并提供独特的机会来获得知识， 并在人们知之甚少的领域培训小鼠病理生物学家， 骨疾病、骨癌、骨质疏松症和 恶性肿瘤 这些项目将建立在 申请人的实验室在病理生理学的骨，癌症， 小鼠高钙血症。 导师将包括：1）担任顾问， 兽医正在攻读实验小鼠病理生物学博士学位（目前 五个DVM的顾问）; 2）担任研究合作导师 兽医和基础科学博士候选人在该部门的项目 兽医生物科学（目前17个项目）和博士候选人在 分子，细胞和发育生物学计划和综合 俄勒冈州立大学癌症中心; 3）参加由 转基因动物共享资源; 4）合作研究项目 涉及小鼠的实验病理生物学;和5）开发训练 小鼠病理生物学的一个项目