POSTDOCTORAL TRAINING

描述(由申请人提供)：该项目的目的是培训内科科学家和博士后科学家在创伤和危重疾病后发生的病理生理过程方面的知识。我们的目标是为这些人的学术生涯做好准备，成为独立的调查人员和教育工作者。通过多学科和协作的努力，学员学习如何识别重要的研究问题，如何设计、进行和分析将解决这些问题的实验，以及如何将他们的发现转化为临床相关的干预措施。 该计划的重要特点包括其多学科培训教师，将授课教育机会与“实践”研究经验相结合，以及在培训院士方面的成功历史。 在接下来的五年里，我们建议在该计划成功培养科学家和临床科学家的历史基础上再接再厉，迎接为未来培养新科学家的挑战。在某种程度上，这些挑战包括美国国立卫生研究院领导人定义的一系列“关键举措”。这些关键举措被称为“美国国立卫生研究院路线图”，直接影响到这一培训计划的结构和方向。简而言之，关键的倡议或主题是三个：(1)发现的新途径，(2)未来的研究团队和(3)临床研究企业的重组。我们建议继续对受训人员进行现有分子生物学技术的教育，并将扩大他们的培训范围，以包括尖端研究和分析(即生物医学计算)技术。通过与基础科学家的合作以及与华盛顿大学现有研究教育项目的整合，我们将让学员接触到基础广泛的研究团队和项目。最后，实习生教育和经验将包括转化性研究的概念，据此，将评估基本观察作为危重患者潜在的诊断和治疗益处。

DESCRIPTION (provided by applicant): The purpose of this program is to train physician-scientists and post-doctoral PhD scientists in aspects of the pathophysiological processes that occur after traumatic injury and critical illness. We aim to prepare these individuals for academic careers as independent investigators and educators. Through a multidisciplinary and collaborative effort, trainees learn how to identify important research questions, how to design, conduct and analyze experiments that will address these questions and how to translate their findings into clinically relevant interventions. Important characteristics of this program include its multidisciplinary training faculty, combining didactic educational opportunities with "hands-on" research experience and a history of success in training academicians. In these next five years, we propose to build upon the Program's history of successfully educating scientists and clinician-scientists and meet the challenges of training new scientists for the future. In part, these challenges include a set of "key initiatives" defined by the leaders at the National Institutes of Health. These key initiatives have been coined the "NIH Roadmap" and have direct bearing on the structure and direction of this training program. Briefly, the key initiatives or themes are three: (1) New Pathways to Discovery, (2) Research Teams of the Future and (3) Reengineering the Clinical Research Enterprise. We propose to continue to educate trainees in established molecular biology techniques and will expand their training to include cutting edge research and analysis (i.e. biomedical computing) techniques. Through collaborations with basic scientists and integration with the available research education programs at the University of Washington, we will expose trainees to broad-based research teams and programs. Finally, trainee education and experience will include concepts of translational research, whereby basic observations will be evaluated as potential diagnostic and therapeutic benefit for critically ill patients.