Gene Polymorphisms, Inflammation and Outcome from Trauma
Gene Polymorphisms, Inflammation and Outcome from Trauma
批准号:
7036560
负责人:
GRANT E O'KEEFE
金额:
$30.35万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2003
资助国家:
美国
项目状态:
已结题
起止时间:
2003-04-01 至 2008-03-31
关键词:
bacterial cytopathogenic effectbacterial diseaseclinical chemistryclinical researchcolonic diverticulosisenzyme linked immunosorbent assayflow cytometrygene expressiongenetic susceptibilitygenotypehuman genetic material taghuman mortalityhuman subjectinflammationinterleukin 6leukocyte activation /transformationlipopolysaccharidesmedical complicationnucleic acid sequenceoutcomes researchpolymerase chain reactionseptic shocksepticemiasingle nucleotide polymorphismtissue resource /registrytrauma
中文摘要
描述(由申请人提供):我们的总体目标是识别和表征对人类对感染和炎症的反应重要的基因差异。首先,我们将使用体内和体外炎症模型来确定炎症相关基因的单核苷酸多态(SNPs)对功能的影响。其次,我们建议确定SNPs,这些SNPs将有助于表征单个患者在受伤后严重感染和死亡的风险。这些信息将使临床医生和研究人员能够更理性地研究和使用旨在减少严重伤害和感染的破坏性后果的特定疗法。
英文摘要
DESCRIPTION (provided by applicant): Our overall aim is to identify and characterize genetic differences that are important to the human response to infection and inflammation. First, we will use in vivo and in vitro models of inflammation to determine the functional impact of single nucleotide polymorphisms (SNPs) in inflammation-related genes. Second, we propose to identify SNPs that will help characterize an individual patient's risk for severe infection and death after injury. This information will allow clinicians and researchers to more rationally investigate and use specific therapies aimed at reducing the devastating consequences of severe injury and infection.
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会议论文
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Gene Polymorphisms, Inflammation and Outcome from Trauma
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资助金额:$31.08万
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Gene Polymorphisms, Inflammation and Outcome from Trauma
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批准号:6795298
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资助金额:$5.0万
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Gene Polymorphisms, Inflammation and Outcome from Trauma
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资助金额:$29.47万
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Gene Polymorphisms, Inflammation and Outcome from Trauma
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项目类别:
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资助金额:$31.08万
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负责人:GRANT E O'KEEFE
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依托单位:
POSTDOCTORAL TRAINING
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财政年份:1975
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依托单位:
POSTDOCTORAL TRAINING
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POSTDOCTORAL TRAINING
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财政年份:1975
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POSTDOCTORAL TRAINING
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POSTDOCTORAL TRAINING
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POSTDOCTORAL TRAINING
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POSTDOCTORAL TRAINING
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海外基金