POSTDOCTORAL TRAINING

描述（由申请人提供）：该计划的目的是培训医生科学家和博士后博士科学家在创伤性损伤和危重病后发生的病理生理过程方面。我们的目标是准备这些人的学术生涯作为独立的调查人员和教育工作者。通过多学科和协作的努力，学员学习如何确定重要的研究问题，如何设计，进行和分析将解决这些问题的实验，以及如何将他们的研究结果转化为临床相关的干预措施。 该计划的重要特点包括其多学科培训教师，将教学教育机会与“动手”研究经验和培养院士的成功历史相结合。 在接下来的五年里，我们建议在该计划成功教育科学家和临床科学家的历史基础上，迎接未来培养新科学家的挑战。在某种程度上，这些挑战包括美国国立卫生研究院领导人定义的一系列“关键举措”。这些关键举措被称为“NIH路线图”，并直接影响到该培训计划的结构和方向。简而言之，关键举措或主题有三个：（1）新的发现途径，（2）未来的研究团队和（3）重新设计临床研究企业。我们建议继续为学员提供分子生物学技术方面的教育，并会扩大培训范围，包括尖端的研究和分析（即生物医学计算）技术。通过与基础科学家的合作，并与华盛顿大学现有的研究教育计划相结合，我们将使学员接触到基础广泛的研究团队和计划。最后，学员的教育和经验将包括转化研究的概念，其中基本观察将被评估为危重患者的潜在诊断和治疗益处。

DESCRIPTION (provided by applicant): The purpose of this program is to train physician-scientists and post-doctoral PhD scientists in aspects of the pathophysiological processes that occur after traumatic injury and critical illness. We aim to prepare these individuals for academic careers as independent investigators and educators. Through a multidisciplinary and collaborative effort, trainees learn how to identify important research questions, how to design, conduct and analyze experiments that will address these questions and how to translate their findings into clinically relevant interventions. Important characteristics of this program include its multidisciplinary training faculty, combining didactic educational opportunities with "hands-on" research experience and a history of success in training academicians. In these next five years, we propose to build upon the Program's history of successfully educating scientists and clinician-scientists and meet the challenges of training new scientists for the future. In part, these challenges include a set of "key initiatives" defined by the leaders at the National Institutes of Health. These key initiatives have been coined the "NIH Roadmap" and have direct bearing on the structure and direction of this training program. Briefly, the key initiatives or themes are three: (1) New Pathways to Discovery, (2) Research Teams of the Future and (3) Reengineering the Clinical Research Enterprise. We propose to continue to educate trainees in established molecular biology techniques and will expand their training to include cutting edge research and analysis (i.e. biomedical computing) techniques. Through collaborations with basic scientists and integration with the available research education programs at the University of Washington, we will expose trainees to broad-based research teams and programs. Finally, trainee education and experience will include concepts of translational research, whereby basic observations will be evaluated as potential diagnostic and therapeutic benefit for critically ill patients.