POSTDOCTORAL TRAINING

描述（申请人提供）：该项目培养创伤性损伤和危重疾病后病理生理过程方面的内科科学家和博士后博士科学家。在过去的4年里，我们成功地招聘到了合适的人才，并解决了我们在之前的竞争性更新中提出的一个关键问题，即我们项目的多样性。我们特别注意识别和招募实力强大、代表性不足的少数族裔候选人。我们之前的竞争性更新也侧重于“关键举措”，由美国国立卫生研究院的领导人定义，称为“NIH路线图”。这直接关系到培训计划的结构和方向。简而言之，关键倡议或主题是：(1)发现的新途径；(2)未来的研究团队；(3)临床研究企业的再造。我们建议继续对学员进行现有分子生物学技术的培训，并将他们的培训扩大到包括前沿研究和分析（即生物医学计算）技术。通过与基础科学家的合作，并与华盛顿大学现有的研究教育项目相结合，我们将使受训者接触到基础广泛的研究团队和项目。培训生的教育和经验将继续包括转化研究的概念，据此，基本观察将被评估为对危重病人的潜在诊断和治疗益处。总之，我们的目标是准备一个不同的群体感兴趣的科学家学术事业作为独立的调查员和教育家。通过多学科合作，学员将学习如何识别重要的研究问题，如何设计、实施和分析将解决这些问题的实验，以及如何将他们的发现转化为临床相关的干预措施。相关性：创伤仍然是一个重要的公共卫生问题。在所有年龄段的人群中，伤害造成的死亡比例很高，对伤害受害者的医疗护理费用高昂。我们的培训项目已经成功地为外科医生、内科医生和博士后提供了损伤和炎症应用生物学方面的培训。我们项目的毕业生已经表现出对损伤生物学的理解和对危重损伤受害者的护理的承诺。

DESCRIPTION (provided by applicant): The program trains physician-scientists and post-doctoral PhD scientists in aspects of the pathophysiological processes that occur after traumatic injury and critical illness. Over the past 4 years we have successfully recruited to fill our positions and have addressed a key concern that was raised in our previous competitive renewal regarding diversity in our program. We have paid particular attention to identifying and recruiting strong under-represented minority candidates. Our previous competitive renewal also focused upon the "key initiatives", defined by the leaders at the National Institutes of Health and termed the "NIH Roadmap". This had direct bearing on the structure and direction of this training program. Briefly, the key initiatives or themes are: (1) New Pathways to Discovery, (2) Research Teams of the Future and (3) Reengineering the Clinical Research Enterprise. We propose to continue to educate trainees in established molecular biology techniques and will expand their training to include cutting edge research and analysis (i.e. biomedical computing) techniques. Through collaborations with basic scientists and integration with the available research education programs at the University of Washington, we will expose trainees to broad-based research teams and programs. Trainee education and experience will continue to include concepts of translational research, whereby basic observations will be evaluated as potential diagnostic and therapeutic benefit for critically ill patients. In summary, we aim to prepare a diverse group of interested scientists for academic careers as independent investigators and educators. Through a multidisciplinary and collaborative effort, trainees learn how to identify important research questions, how to design, conduct and analyze experiments that will address these questions and how to translate their findings into clinically relevant interventions. RELEVANCE: Trauma remains an important public health problem. Injuries are responsible for a high proportion of deaths in people of all ages and medical care for injury victims is costly. Our training program has successfully educated surgeons, physicians and post-doctoral students in aspects of the applied biology of injury and inflammation. Graduates from our program have demonstrated a commitment to understanding the biology of injury and to the care of critically ill injury victims.