28th International Herpesvirus Workshop,

第28届国际疱疹病毒研讨会，

• 批准号: 6673329
• 负责人: JAY A NELSON
• 金额: $ 3.35万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-15 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6673329
• 关键词: DNA virus; Herpesviridae; travel; workshop

DESCRIPTION (provided by applicant): This proposal requests funds to enable young investigators to attend the 28th International Herpesvirus Workshop at the Monona Terrace Convention Center, Madison, Wisconsin, July 26-August 1, 2003. The International Herpesvirus Workshop is the premier scientific meeting for herpesvirus researchers, and the only meeting with an interdisciplinary focus on all the major subfamilies of herpesviruses and all aspects of research from molecular biology to clinical studies. The strength of the Workshop rests on the cross-fertilization that results from comparison of different herpesviruses, different approaches to key questions and on the support and participation of leading researchers in the field, most significantly including promising young investigators and students in training. Moreover, the forum is truly international, with broad-based world-wide attendance. The medical importance of this meeting is clearly indicated from the wide variety of diseases caused by the now recognized eight human herpesviruses. These include skin and eye ulcerations (HSV-1), genital lesions (HSV-2), meningitis and encephalitis (HSV-1 and HSV-2), infectious mononucleosis (EBV), chicken pox and shingles (VZV). CMV is a major cause of birth defects including mental retardation, blindness and deafness due to congenital transmission but also a significant opportunistic pathogen in AIDS patients and organ transplant recipients. More recently, CMV and HSV have been implicated as pathogenic contributors in the development of atherosclerosis. Cancer has also been associated with herpesvirus infections. EBV is associated with Burkitt's lymphoma, other B cell neoplasias and nasopharyngeal carcinoma. The most recent human herpesvirus discovered (HHV-8 or KSHV) is associated with Kaposi' sarcoma in AIDS patients and other immunosupressed persons and in other groups. All of the herpesviruses persist for life and therefore pose significant problems in the treatment of immunologically compromised persons. Diseases caused by reactivation of most human herpesviruses are a significant cause of morbidity and mortality in various immune patient populations. Shingles and post-herpetic neuralgia are problems in the elderly. Animal herpesviruses are of significant economic importance to poultry (Marek's and others), swine (pseudorabies virus), cattle (several bovine herpesviruses) and horses (several equine herpesviruses). In addition, these animal herpesviruses serve as important model systems for studying herpesvirus pathogenesis. Finally, recombinant DNA technology permits the design of novel vaccines for controlling the spread of animal herpesvirus infection and the design of herpesvirus vectors for gene therapy. Workshop sessions will take an interdisciplinary approach to the following topics: virus structure, mechanism of virus entry and cell-cell spread, membrane proteins, pathogenesis and latency, DNA replication, vaccination and the immune response, transcriptional control, regulation of gene expression, chemotherapeutic targets, and virus gene therapy.

描述(由申请者提供)：本提案要求提供资金，使年轻研究人员能够参加2003年7月26日至8月1日在威斯康星州麦迪逊市莫诺纳露台会议中心举行的第28届国际疱疹病毒研讨会。国际疱疹病毒研讨会是疱疹病毒研究人员的首要科学会议，也是唯一一次跨学科重点关注疱疹病毒所有主要亚家族以及从分子生物学到临床研究的所有方面的会议。讲习班的优势在于通过比较不同的疱疹病毒、解决关键问题的不同方法以及该领域主要研究人员的支持和参与而产生的相互影响，其中最重要的是包括有前途的年轻研究人员和学生参加培训。此外，该论坛是真正的国际化，有广泛的基础，世界各地的人参加。现在公认的八种人类疱疹病毒引起的各种疾病清楚地表明了这次会议的医学重要性。这些疾病包括皮肤和眼睛溃疡(HSV-1)、生殖器病变(HSV-2)、脑膜炎和脑炎(HSV-1和HSV-2)、传染性单核细胞增多症(EBV)、水痘和带状疱疹(VZV)。巨细胞病毒是导致先天传播所致智力低下、失明和耳聋等出生缺陷的主要原因，也是艾滋病患者和器官移植受者的重要机会性病原体。最近，巨细胞病毒和单纯疱疹病毒被认为是动脉粥样硬化发展的致病因素。癌症也与疱疹病毒感染有关。EBV与Burkitt淋巴瘤、其他B细胞肿瘤和鼻咽癌有关。最近发现的人类疱疹病毒(HHV-8或KSHV)与艾滋病患者和其他免疫抑制者以及其他人群中的卡波西肉瘤有关。所有的疱疹病毒都会持续一生，因此在治疗免疫功能受损的人时会造成重大问题。由大多数人类疱疹病毒重新激活引起的疾病是各种免疫患者群体发病率和死亡率的重要原因。带状疱疹和带状疱疹后神经痛是老年人的问题。动物疱疹病毒对家禽(马立克氏病等)、猪(伪狂犬病病毒)、牛(几种牛疱疹病毒)和马(几种马疱疹病毒)具有重要的经济意义。此外，这些动物疱疹病毒也是研究疱疹病毒发病机制的重要模型系统。最后，重组DNA技术允许设计控制动物疱疹病毒感染传播的新型疫苗和设计用于基因治疗的疱疹病毒载体。 研讨会将对以下主题采取跨学科的方法：病毒结构、病毒进入和细胞-细胞传播的机制、膜蛋白、致病机制和潜伏期、DNA复制、疫苗接种和免疫反应、转录调控、基因表达调控、化疗靶点和病毒基因治疗。