Medical imaging and analysis of blood flow in healthy and diseased microcirculations

健康和患病微循环中血流的医学成像和分析

• 批准号: 2596864
• 金额: --
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2596864
• 关键词: Medical; imaging; analysis; blood; flow

In this project, we will develop Haemoglobin Video Imaging (HVI), a rapid, safe, and non-invasive technique that demonstrates conjunctival microcirculations with single-cell resolution. In general, microcirculations of the peripheral vascular system are poorly understood because most microvasculature cannot be imaged and re-visited clinically. HVI will be applied to allow investigation of microcirculatory physiology and pharmacology in health and disease, and to establish diagnostic and treatment parameters.HVI employs a modified slit-lamp, an optical device used routinely for ophthalmic examination. The surface of the eye is illuminated with a green waveband absorbed by Haemoglobin. This yields high-contrast, high-resolution videos of dark erythrocytes against a bright background of light. Presently, images are degraded by involuntary micro-saccadic eye movements, respiration, and heart action, preventing quantitative analysis. Years 1 to 2 of the project will involve optical and control engineering to achieve continuous autofocus on the conjunctival microcirculations. Later years of the project will focus on vision computing and analysis of the stabilized blood flow, with clinical investigation of microcirculation changes during systemic diseases like diabetes, systemic sclerosis, systemic vasculitis, and hypertension.Relevant EPSRC research areas:1. Medical Imaging (Including Medical Image and Vision Computing)2. Image And Vision Computing3. Control Engineering4. Optical Devices and Subsystems5. Complex Fluids and Rheology

在这个项目中，我们将开发血红蛋白视频成像（HVI），这是一种快速，安全和非侵入性的技术，可以用单细胞分辨率显示结膜微循环。一般来说，外周血管系统的微循环知之甚少，因为大多数微血管不能成像和临床再访。HVI将被应用于健康和疾病的微循环生理学和药理学的研究，并建立诊断和治疗参数。HVI采用了一种改进的裂隙灯，这是一种常规用于眼科检查的光学设备。眼睛表面被血红蛋白吸收的绿色波段照亮。这产生了高对比度，高分辨率的视频暗红细胞对明亮的背景光。目前，图像被无意识的微扫视眼球运动、呼吸和心脏动作降级，从而阻止定量分析。该项目的第1年至第2年将涉及光学和控制工程，以实现对结膜微循环的连续自动聚焦。该项目的后期将集中在视觉计算和稳定血流的分析，以及糖尿病，系统性硬化症，系统性血管炎和高血压等系统性疾病微循环变化的临床研究。相关EPSRC研究领域：1.医学影像（包括医学影像及视觉计算）2.图像和视觉计算3.控制工程4.光学器件和子系统5.复杂流体与流变学