Mayo Alzheimer's Disease Research Center

描述（由申请人提供）：梅奥阿尔茨海默病研究中心（ADRC）位于罗切斯特，MN和杰克逊维尔，FI，将追求两个主要主题：1)招募和表征阿尔茨海默病（AD）退行性谱系的受试者，特别关注早期疾病，轻度认知障碍（MCI）； 2)招募和表征非阿尔茨海默病痴呆的受试者，包括额颞叶痴呆，路易体痴呆和皮质基底变性。这两个主题是抗联目前活动的延续。在当前的资助周期中，ADRC一直活跃于MCI的临床、神经心理学、神经影像学和神经病理学方面的研究，并将在拟议的资助周期中继续这些努力。该中心还强调了额颞叶痴呆、路易体痴呆和皮质基底变性的研究，这项工作将在拟议的资助期内扩大。ADRC将包括4个核心：临床核心、生物统计学和数据管理核心、神经病理学核心和教育和信息传递核心。每个核心都由各自领域的专家领导。该中心还将包括3个项目：1)基于张量的区域萎缩率测量，来自序列结构MRI和正常衰老，AD和FTD； 2)额颞叶痴呆和运动神经元疾病的遗传学；3)10号染色体IDE区域AD的易感等位基因。核心和项目将直接交互。所有3个项目将利用临床，生物统计学和数据管理和神经病理学核心。该中心旨在开展与中心主题一致的研究，并在机构内促进AD研究。

DESCRIPTION (provided by applicant): The Mayo Alzheimer's Disease Research Center (ADRC) is located in Rochester, MN and Jacksonville, FI and will pursue two primary themes: 1) The recruitment and characterization of subjects on the Alzheimer's disease (AD) degenerative spectrum with a particular focus on early stage disease, mild cognitive impairment (MCI), and 2) the recruitment and characterization of subjects with non-AD dementias including frontotemporal dementia, dementia with Lewy bodies and corticobasal degeneration. These two themes represent a continuation of current activities of the ADRC. The ADRC in its current funding cycle has been active in research on the clinical, neuropsychological, neuroimaging and neuropathological aspects of MCI and will continue these efforts in proposed grant cycle. The Center has also emphasized research in frontotemporal dementia, dementia with Lewy bodies and corticobasal degeneration as well, and this work will expand in the proposed grant period. The ADRC will include 4 Cores: Clinical Core, Biostatistics and Data Management Core, Neuropathology Core and Education and Information Transfer Core. Each of these Cores is led by experts in their respective areas. The Center will also include 3 Projects: 1) Tensor Based Regional Atrophy Rate Measures from Serial Structure MRI and Normal Aging, AD and FTD, 2) The Genetics of Frontotemporal Dementia and Motor Neuron Disease, and 3) Susceptibility Alleles for AD in the IDE Region on Chromosome 10. The Cores and Projects will interact directly. All 3 Projects will draw upon the Clinical, Biostatistics and Data Management and Neuropathology Cores. The Center is designed to conduct research consistent with the themes of the Center and promote AD research within the institution.