MAYO ALZHEIMER'S DISEASE RESEARCH CENTER-SUPPLEMENT

拟建的梅奥阿尔茨海默病研究中心(ADRC)将建立 根据之前资助的梅奥阿尔茨海默病的经历 中心(P30)和佛罗里达州梅奥·杰克逊维尔和梅奥的新教职员工 亚利桑那州斯科茨代尔将解决老龄化和阿尔茨海默氏症的研究问题 疾病(AD)。ADRC将由五个核心组成：行政核心、 临床和研究支持核心，神经病理学和遗传学核心， 神经成像核心和教育和信息传输核心，以及两个 项目：项目1：脑神经退行性变中的细胞骨骼病理学 AD，“项目”白质疏松症对认知障碍的贡献 在老龄化和阿尔茨海默氏症方面。 科学主题，包括痴呆症和AD的神经流行病学， 正常衰老与阿尔茨海默病的界限及认知预测因子 无症状者的损害。梅奥任命新教职员工 杰克逊维尔：淀粉样蛋白加工的基础科学，tau，遗传学 抗体的开发将补充临床和流行病学 中心其余部分的专业知识。斯科茨代尔的调查人员 将在高危对象中增加功能成像研究，以追求 中心的科学主题。拟议的亚洲发展研究中心将延长 提高现有阿尔茨海默病中心的工作效率并开发新的 对衰老和AD的洞察。

The proposed Mayo Alzheimer's Disease Research Center (ADRC) will build upon the experience of the previously funded Mayo Alzheimer's Disease Center (P30) and the new faculty at Mayo Jacksonville, FL and the Mayo Scottsdale, AZ to address research questions in aging and Alzheimer's disease (AD). The ADRC will consist of five cores: Administrative Core, Clinical and Research Support Core, Neuropathology and Genetics Core, Neuroimaging Core and Education and Information Transfer Core, and two projects: Project 1: "Cytoskeletal Pathology in the Neurodegeneration of AD,"Project "The contribution of Leukoaraisosis to Cognitive Impairment in Aging and Alzheimer's Disease." The Center will address several scientific themes including neuroepidemiology of dementia and AD, the boundary between normal aging and AD, and predictors of cognitive impairment in asymptomatic persons. New faculty appointments in Mayo Jacksonville in the basic science of amyloid processing, tau, genetics and antibody development will complement the clinical and epidemiology expertise in the remainder of the Center. Investigators in Scottsdale will add functional imaging studies in at-risk subjects to pursue the scientific themes of the Center. The proposed ADRC will extend the productivity of the existing Alzheimer's Disease Center and develop new insights into aging and AD.