Mayo Alzheimer's Disease Research Center

马约阿尔茨海默病研究中心（ADRC）位于罗切斯特，明尼苏达州和杰克逊维尔，佛罗里达州，并将追求两个主题：1）招募和表征处于从衰老到阿尔茨海默病（AD）的认知谱的早期阶段的受试者，特别关注轻度认知障碍（MCI），（2）非AD性痴呆的研究，包括额颞叶变性和路易体痴呆。ADRC将由5个核心组成：行政核心、临床核心、数据管理和统计核心、神经病理学核心以及教育和信息传输核心。这些核心将相互作用，并将支持三个拟议的研究项目：1）识别路易体痴呆症和AD的多模态成像相关性，2）阿尔茨海默病和神经变性中的PGRN/TDP-43轴，以及3）通过基因表达的全基因组关联识别AD风险变体。这些核心将由实地的资深调查员领导，三个项目将由在各自研究领域较年轻但经验丰富和富有成效的调查员指导，他们过去不是项目领导人。这三个人都在ADRC环境中接受了痴呆症研究领域杰出研究人员的培训，他们将继续探索成熟的研究主题。在目前的赠款周期内，亚洲减灾中心的工作人员编制了340份出版物、70个章节和276份摘要，并将在拟议的赠款周期内继续保持这一生产力。该中心将继续其关于《城市发展战略》的工作，并为全国住房协调委员会数据库作出贡献。MCI、神经影像学和临床病理相关性的研究将通过核心和项目之间的密切合作继续进行。该中心也将继续成为年轻调查人员的培训平台。

The Mayo Alzheimer's Disease Research Center (ADRC) is located in Rochester, MN and Jacksonville, FL and will pursue two themes: 1) The recruitment and characterization of subjects in the early stages of the cognitive spectrum from aging to Alzheimer's disease (AD) particularly focusing on mild cognitive impairment (MCI), and 2) the study of non-AD dementias including frontotemporal lobar degeneration and dementia with Lewy bodies. The ADRC will consist of 5 cores: Administrative Core, Clinical Core, Data Management and Statistics Core, Neuropathology Core and Education and Information Transfer Core. The cores will interact with each other and will support three proposed research projects: 1) Identifying Multi-modality Imaging Correlates of Dementia with Lewy Bodies and AD, 2) The PGRN/TDP-43 Axis in Alzheimer's Disease and Neurodegeneration, and 3) Identification of AD Risk Variants by Genome Wide Association of Gene Expression. The cores will be led by established investigators in the field and the three projects will be directed by younger but experienced and productive investigators in their respective areas of research who have not been project leaders in the past. All three were trained in the ADRC environment by prominent investigators in dementia research and they will continue to explore well-established research themes. The ADRC staff has produced 340 publications, 70 chapters and 276 abstracts in the current grant cycle and will continue this productivity in the proposed grant cycle. The Center will continue its work on the UDS and contribute to the NACC database. Research on MCI, neuroimaging and clinical-pathological correlations will continue through the intense collaboration among the cores and projects. The ADRC will also continue to be a training platform for young investigators.