MAYO ALZHEIMERS DISEASE RESEARCH CENTER

拟议中的马约阿尔茨海默病研究中心（ADRC）将建立 根据以前资助的马约阿尔茨海默病的经验， 中心（P30）和佛罗里达州杰克逊维尔马约和马约的新教师 斯科茨代尔，亚利桑那州，以解决衰老和阿尔茨海默氏症的研究问题 疾病（AD）。ADRC将由五个核心组成：行政核心， 临床和研究支持核心，神经病理学和遗传学核心， 神经影像学核心和教育和信息传输核心，以及两个 项目：项目1：“神经退行性变的细胞骨架病理学” AD，“项目“脑白质疏松症对认知障碍的贡献 老龄化和阿尔茨海默病“该中心将解决几个 科学主题，包括痴呆症和AD的神经流行病学， 正常衰老和AD之间的界限，以及认知功能的预测因素 无症状者的损伤。马约的新教师任命 杰克逊维尔在淀粉样蛋白加工，tau蛋白，遗传学的基础科学 抗体的开发将补充临床和流行病学 在中心的其余部分的专业知识。斯科茨代尔的调查人员 将在高危受试者中增加功能成像研究， 中心的科学主题。拟议的发展检讨委员会将把 现有阿尔茨海默病中心的生产力，并开发新的 对衰老和AD的见解。

The proposed Mayo Alzheimer's Disease Research Center (ADRC) will build upon the experience of the previously funded Mayo Alzheimer's Disease Center (P30) and the new faculty at Mayo Jacksonville, FL and the Mayo Scottsdale, AZ to address research questions in aging and Alzheimer's disease (AD). The ADRC will consist of five cores: Administrative Core, Clinical and Research Support Core, Neuropathology and Genetics Core, Neuroimaging Core and Education and Information Transfer Core, and two projects: Project 1: "Cytoskeletal Pathology in the Neurodegeneration of AD,"Project "The contribution of Leukoaraisosis to Cognitive Impairment in Aging and Alzheimer's Disease." The Center will address several scientific themes including neuroepidemiology of dementia and AD, the boundary between normal aging and AD, and predictors of cognitive impairment in asymptomatic persons. New faculty appointments in Mayo Jacksonville in the basic science of amyloid processing, tau, genetics and antibody development will complement the clinical and epidemiology expertise in the remainder of the Center. Investigators in Scottsdale will add functional imaging studies in at-risk subjects to pursue the scientific themes of the Center. The proposed ADRC will extend the productivity of the existing Alzheimer's Disease Center and develop new insights into aging and AD.