Mayo Alzheimer's Disease Research Center

简介（由申请人提供）：2012年5月，国家发布了第一个《国家阿尔茨海默病防治计划》，为阿尔茨海默病（AD）的研究制定了蓝图，目标是到2025年实现有效治疗和预防该病的目标。为了实现这一目标，梅奥阿尔茨海默病研究中心（ADRC）正在进行研究以实现这一目标。该中心将由五个核心组成：行政核心，负责监督中心的业务；临床核心招募和描述阿尔茨海默病谱系和阿尔茨海默病相关痴呆的受试者；数据管理和统计核心，收集、提炼和分析数据，符合国家阿尔茨海默病协调中心的要求；神经病理学中心对尸检标本进行详细的神经病理学研究，并向合作者传播遗传和其他生物标本；外联，招聘和教育核心，以协助招聘和表征研究目的的主题。ADRC还提出了三个新的研究项目，其中一个是由一名初级研究员进行的。项目1，“利用影像学改善痴呆病理和长期预后的临床预测”，由Prashanthi Vemuri博士负责，将开发一种使用临床和影像学数据预测痴呆亚型的软件方法；项目2，“验证HDAC6作为阿尔茨海默病的新治疗靶点”，首席研究员Leonard Petrucelli博士将验证胞质组蛋白去乙酰化酶6的抑制作用

DESCRIPTION (provided by applicant): The First National Plan to Address Alzheimer's Disease was released in May of 2012 and set a blueprint for research in Alzheimer's disease (AD) to achieve the goal of effective treatment and prevention of the disease by 2025. Toward that goal, the Mayo Alzheimer's Disease Research Center (ADRC) is pursuing research to accomplish that goal. The Center will be comprised of five cores: Administrative Core to oversee the operations of the Center; Clinical Core to recruit and characterize subjects along the AD spectrum and for the AD-related dementias; Data Management and Statistical Core to collect, refine and analyze data and be compliant with the requirements of the National Alzheimer's Coordinating Center; Neuropathology Core to perform detailed neuropathological studies on autopsy specimens and disseminate genetic and other biospecimens to collaborators; Outreach, Recruitment and Education Core to assist in the recruitment and characterization of subjects for research purposes. The ADRC is also proposing three new research projects including one by a junior investigator. Project 1, "Improving Clinical Prediction of Dementia Pathology and Long-Term Outcomes Using Imaging," by Prashanthi Vemuri, Ph.D., will develop a software methodology using clinical and imaging data to predict dementia subtypes; Project 2, "Validating HDAC6 as a Novel Therapeutic Target for Alzheimer's Tauopathy," principal investigator Leonard Petrucelli, Ph.D., will validate inhibition of cytosolic histone deacetylase 6 that modulates the accumulation of hyperphosphorylated tau as a possible strategy for the treatment of AD; Project 3, "ApoE Isoforms in Brain Vasculature and CAA," Goujun Bu, Ph.D., will investigate the roles of ApoE and ApoE receptors in the pathogenesis of AD. The ADRC will continue to maintain an active cohort of research subjects and will recruit a new cohort of at-risk subjects for Lewy body disorders. The Center will continue to serve as the nidus for AD research at the Mayo Clinic and will interact with the National Institute on Aging and other Alzheimer's Disease Centers around the country. The Center will remain flexible and adapt to new directions as the field of AD and related dementia research progresses.