Pediatric Clinical Research Scholar Program - Washington

描述（申请人提供）： 本申请建议在华盛顿，华盛顿特区开发NCRR儿科临床研究学者（PCRS）项目，作为儿童国家医学中心/乔治华盛顿大学医学与健康科学学院（CNMC/GW）、乔治敦大学医学中心（GUMC）和霍华德大学医院（HUH）之间的联合努力。CNMC将担任牵头机构，并申请这笔赠款。PCRS计划的目标是增加训练有素和创新的儿科临床研究人员的数量，他们能够设计和进行以患者为导向的研究的所有阶段，并将成为多学科临床研究工作的领导者。在整个计划（2-5年）中，学者将获得75-90%的保护时间，并将接受以患者为导向的研究培训，目标是在他们参与该计划结束时获得独立的NIH资助。在CNMC，GUMC和HUH的三个NCRR资助的GCRC提供的基础设施下，相信作为独立儿科临床研究者的成功职业生涯是每位学者可以实现的目标。申请人将在第一个五年奖学金期间共招收12名学者。此外，他们将招收两名额外的“学者”使用机构CNMC基金作为匹配赠款。将从内部和外部征聘警察和志愿人员候选人，重点是妇女、代表人数不足的少数民族和残疾人。个性化和结构化的PCRS培训计划将包括：1）临床研究方法学的基础和全面的指导培训; 2）与临床研究相关的必修课程，可以获得研究生学位; 3）负责任地进行研究的培训;以及4）涉及三个GCRC中的一个或多个的强化监督临床研究项目。个人学习计划将在21位首席导师之一的指导下进行，并在需要时得到其他导师和支持教师的帮助，并将在三个机构中进行整合。导师已在广泛的学科选择，以便能够培养具有不同研究兴趣的学者。申请人还从联合会提出了8名潜在的PCRS候选人，其中5名是妇女，5名来自少数群体，1名有残疾。现有的临床研究培训领域包括：行为医学和临床神经科学，研究兴趣包括注意力缺陷多动障碍（ADHD）、语言障碍、进食障碍和抑郁症;遗传医学，研究镰状细胞病、血色病、先天性代谢缺陷、高血压和肌营养不良症;肿瘤学，研究脑肿瘤和白血病;血液学、免疫学和传染病，研究艾滋病毒、输血和丙型肝炎、铁过载和疫苗开发;实验治疗学，研究癌症、传染病和神经系统疾病的药物试验;卫生服务和公共卫生研究，研究婴儿死亡率、暴力预防、青少年艾滋病毒预防以及受伤或严重疾病的后果预测。

DESCRIPTION (Provided by the applicant): This application proposes to develop an NCRR Pediatric Clinical Research Scholars (PCRS) Program in Washington, D.C. as a consortium effort between Children's National Medical Center/George Washington University School of Medicine and Health Sciences (CNMC/GW), Georgetown University Medical Center (GUMC), and Howard University Hospital (HUH). CNMC will serve as the lead institution and is the applicant for this grant. The goal of the PCRS program is to increase the number of well-trained and innovative pediatric clinical investigators who are able to design and conduct all phases of patient-oriented research and who will become leaders of multidisciplinary clinical research efforts. The Scholars will be guaranteed 75-90% protected time throughout the program (2-5 years) and will be provided training in patient-oriented research, with the goal of achieving independent NIH funding by the end of their participation in the program. With the infrastructure provided by the three NCRR-funded GCRCs at CNMC, GUMC and HUH, it is believed that a successful career as an independent pediatric clinical investigator is an achievable goal for each Scholar. The applicants will enroll a total of 12 Scholars during the first five years award period. In addition, they will enroll two additional "Scholars" using institutional CNMC funds as a matching grant. Both internal and external recruitment of PCRS candidates will be pursued, with an emphasis on women, underrepresented minorities, and individuals with disabilities. The individualized and structured PCRS training program will include: 1) Fundamental and comprehensive mentored training in clinical research methodology; 2) Mandatory courses relevant to clinical research that can lead to a post-graduate degree; 3) Training in the responsible conduct of research; and 4) An intensive supervised clinical research project involving one or more of the three GCRCs. Individual programs of study will be performed under the guidance of one of the 21 Lead Mentors with the help of other mentors and support faculty if required, and will be integrated across the three institutions. Mentors have been selected in a wide range of disciplines in order to be able to train Scholars with diverse research interests. The applicants also present eight potential PCRS candidates from the consortium, five of whom are women, five are from minority groups and one has a disability. Available clinical research training areas include: Behavioral medicine and clinical neuroscience with research interests in attention deficit hyperactivity disorder (ADHD), language disorders, feeding disorders, and depression; Genetic medicine with research in sickle cell disease, hemochromatosis, inborn errors of metabolism, hypertension and muscular dystrophies; Oncology, with studies in brain tumors and leukemia; Hematology, immunology and infectious diseases with research in HIV, transfusion and Hepatitis C, iron overload and vaccine development; Experimental therapeutics with drug trials in cancer, infectious diseases, and neurological disorders; and Health services and Public Health research with research in infant mortality, violence prevention, HIV prevention in adolescents, and prediction of outcome following injury or severe illness.