Children's Research Institute Hematology Research Training Grant

儿童研究所血液学研究培训补助金

• 批准号: 8607589
• 负责人: NAOMI L LUBAN
• 金额: $ 29.67万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-01 至 2017-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8607589
• 关键词: Child; Grant; Hematology; Research Institute; Research Training

PROJECT SUMMARY The conduct of high quality and transformative research in pediatric transfusion medicine and hematology is complicated by several barriers including, 1) lack of a robust infrastructure for research training and implementation; 2) shortage of mid-career and senior investigators to serve as research mentors; 3) need for multidisciplinary translational approaches to answer critical clinical questions; 4) lack of diversity among clinical and translational investigators with respect to minority status and gender despite a disproportionate number of under-represented infants and children minority with diseases and disorders which could benefit from such investigations. We use this application to propose a highly collaborative and multidisciplinary, inter-institutional program of mentored training for future scientists in pediatric transfusion medicine and hematology that will address these barriers. It will focus on advancing clinical and translational scholarship on the diagnosis and clinical management of hematological, cardiovascular and pulmonary disorders, transfusion and transplantation. The program, the Pediatric Hematology and Transfusion Medicine Multidisciplinary Research Training Award (PHTMMRT) will have the long-term objective of preparing trainees from diverse backgrounds for academic leadership and independently funded research careers. Each trainee in the program will complete a Master's Degree in Clinical and Translational Science (MsCTR) at the George Washington University School of Medicine and Health Sciences (GWU) and will devise, implement and complete a research project under the joint oversight of multidisciplinary mentorship team. At the completion of the three year program, each trainee will have presented his/her data at least at one national research meeting, drafted and submitted one or more manuscripts suitable for external peer-reviewed publications, and submitted an external grant application to the NIH or equivalent funding source. The program will be overseen by two highly qualified and NIH-funded Principal Investigators/Program Directors (PIs/PDs) with distinct and complementary clinical backgrounds and research expertise. They will be supported by 9 faculty of Children's National and its affiliated GWU School of Medicine and Health Sciences (GWU) with 9 external mentors who are research scientists with expertise in coagulation, transfusion medicine, transplantation, sickle cell disease and vascular biology. A Diversity Enhancement Officer, a full professor and funded investigator, will assist in the recruitment of minority, disabled or disadvantaged applicants, and women. Finally, an External Advisory Committee, composed of 6 NIH-funded national leaders in transfusion medicine and hematology with established career mentorship programs, will offer annual feedback and guidance with respect to development of the PHTMMRT program and to the trainees' progress. The PHTMMRT program will directly address each of the barriers noted above by leveraging several of Children's National's (CNMC) multiple and pre-existing strengths with collaborating neighboring research institutions including the NIH, American Red Cross, FDA and Howard University School of Medicine which provide outstanding training opportunities. These strengths include 1.a) the availability of translational and clinical scientists across the full spectrum from mechanistic investigations to health services research; 1.b) a pool of experienced NIH funded faculty who with our external mentors provide access to unparalleled core facilities and research training; 2) our large, local community of K Scholars and other trainees which, through a Council of Trainees, will provide collegial, formal and informal, interdisciplinary learning opportunities in team science; 3) our robust CTSA-funded infrastructure for supporting trainee research, including a MS in Clinical and Translational Research; 4) our longstanding commitment to recruit and train investigators from diverse clinical disciplines who are under-represented minorities or women. Our multidisciplinary, inter-institutional mentors will train four future academic leaders in Pediatric Hematology and Transfusion Medicine, who will lead both clinical and translational research teams, compete successfully for grant support and provide novel insights into the causes, pathophysiology and treatment of pediatric diseases that affect the Nation's children.

项目摘要 在儿科输血医学和血液学方面进行高质量和变革性的研究， 复杂的几个障碍，包括：1）缺乏一个强大的基础设施的研究培训， 2）缺乏担任研究导师的中级和高级调查员; 3）需要 多学科翻译方法来回答关键的临床问题; 4）临床之间缺乏多样性 和翻译调查人员在少数民族地位和性别方面的情况，尽管有不成比例的人数 代表性不足的婴儿和患有疾病和失调的儿童， 调查事务所 我们使用此应用程序提出了一个高度协作和多学科，跨机构的计划， 指导培训未来的科学家在儿科输血医学和血液学，将解决这些问题 隔栏.它将专注于推进临床和翻译奖学金的诊断和临床 血液、心血管和肺部疾病的管理、输血和移植。的 儿科血液学和输血医学多学科研究培训 奖（PHTMMRT）将有准备来自不同背景的学员的长期目标， 学术领导和独立资助的研究事业。参加该计划的每个学员将完成一份 乔治华盛顿大学医学院临床和转化科学硕士学位（MsCTR） 医学和健康科学（GWU），并将设计，实施和完成一个研究项目， 联合监督多学科指导小组。在三年计划结束时，每个学员 至少在一次国家研究会议上提交了他/她的数据，起草并提交了一份或多份 手稿适合外部同行评审的出版物，并提交了外部赠款申请， NIH或同等资金来源。该计划将由两名高素质和NIH资助的 具有独特且互补的临床背景的主要研究者/项目总监（PI/PD）， 研究专长。他们将得到儿童国家及其附属GWU学校的9名教师的支持。 医学和健康科学（GWU），有9名外部导师，他们是具有以下专业知识的研究科学家： 凝血、输血医学、移植、镰状细胞病和血管生物学。分集 加强干事是一名全职教授和受资助的调查员，将协助征聘少数族裔， 残疾或弱势申请人以及妇女。最后，一个外部咨询委员会，由6名 NIH资助的输血医学和血液学领域的国家领导人，并建立了职业导师制 计划，将提供关于PHTMMRT计划发展的年度反馈和指导， 学员的进步。 PHTMMRT计划将通过利用以下几个方面直接解决上述每个障碍： 儿童国家（CNMC）的多重和预先存在的优势与合作的邻近研究 包括NIH、美国红十字会、FDA和霍华德大学医学院在内的机构， 提供良好的培训机会。这些优势包括：1.a）翻译和 从机械研究到卫生服务研究的全方位临床科学家; 1.b）a 一群经验丰富的NIH资助的教师，他们与我们的外部导师一起提供无与伦比的核心知识。 设施和研究培训; 2）我们的K学者和其他学员的大型当地社区，通过 学员理事会将提供正式和非正式的学院式跨学科团队学习机会 科学; 3）我们强大的CTSA资助的基础设施，用于支持实习生的研究，包括临床MS 和转化研究; 4）我们长期致力于招募和培训来自不同领域的研究人员 临床学科中少数民族或女性代表不足。 我们的多学科，跨机构的导师将培养四个未来的儿科血液学学术领袖 和输血医学，谁将领导临床和转化研究团队，竞争成功 获得拨款支持，并提供新的见解的原因，病理生理学和治疗儿科 影响国家儿童的疾病。