Children's Research Institute Hematology Research Training Grant

儿童研究所血液学研究培训补助金

• 批准号: 8213944
• 负责人: NAOMI L LUBAN
• 金额: $ 7.3万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-01 至 2017-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8213944
• 关键词: Child; Grant; Hematology; Research Institute; Research Training

DESCRIPTION (provided by applicant): The conduct of high quality and transformative research in pediatric transfusion medicine and hematology is complicated by several barriers including, 1) lack of a robust infrastructure for research training and implementation; 2) shortage of mid-career and senior investigators to serve as research mentors; 3) need for multidisciplinary translational approaches to answer critical clinical questions; 4) lack of diversity among clinical and translational investigators with respect to minority status and gender despite a disproportionate number of under-represented infants and children minority with diseases and disorders which could benefit from such investigations. We use this application to propose a highly collaborative and multidisciplinary, inter-institutional program of mentored training for future scientists in pediatric transfusion medicine and hematology that will address these barriers. It will focus on advancing clinical and translational scholarship on the diagnosis and clinical management of hematological, cardiovascular and pulmonary disorders, transfusion and transplantation. The program, the Pediatric Hematology and Transfusion Medicine Multidisciplinary Research Training Award (PHTMMRT) will have the long-term objective of preparing trainees from diverse backgrounds for academic leadership and independently funded research careers. Each trainee in the program will complete a Master's Degree in Clinical and Translational Science (MsCTR) at the George Washington University School of Medicine and Health Sciences (GWU) and will devise, implement and complete a research project under the joint oversight of multidisciplinary mentorship team. At the completion of the three year program, each trainee will have presented his/her data at least at one national research meeting, drafted and submitted one or more manuscripts suitable for external peer-reviewed publications, and submitted an external grant application to the NIH or equivalent funding source. The program will be overseen by two highly qualified and NIH-funded Principal Investigators/Program Directors (PIs/PDs) with distinct and complementary clinical backgrounds and research expertise. They will be supported by 9 faculty of Children's National and its affiliated GWU School of Medicine and Health Sciences (GWU) with 9 external mentors who are research scientists with expertise in coagulation, transfusion medicine, transplantation, sickle cell disease and vascular biology. A Diversity Enhancement Officer, a full professor and funded investigator, will assist in the recruitment of minority, disabled or disadvantaged applicants, and women. Finally, an External Advisory Committee, composed of 6 NIH-funded national leaders in transfusion medicine and hematology with established career mentorship programs, will offer annual feedback and guidance with respect to development of the PHTMMRT program and to the trainees' progress. The PHTMMRT program will directly address each of the barriers noted above by leveraging several of Children's National's (CNMC) multiple and pre-existing strengths with collaborating neighboring research institutions including the NIH, American Red Cross, FDA and Howard University School of Medicine which provide outstanding training opportunities. These strengths include 1.a) the availability of translational and clinical scientists across the full spectrum from mechanistic investigations to health services research; 1.b) a pool of experienced NIH funded faculty who with our external mentors provide access to unparalleled core facilities and research training; 2) our large, local community of K Scholars and other trainees which, through a Council of Trainees, will provide collegial, formal and informal, interdisciplinary learning opportunities in team science; 3) our robust CTSA-funded infrastructure for supporting trainee research, including a MS in Clinical and Translational Research; 4) our longstanding commitment to recruit and train investigators from diverse clinical disciplines who are under-represented minorities or women. Our multidisciplinary, inter-institutional mentors will train four future academic leaders in Pediatric Hematology and Transfusion Medicine, who will lead both clinical and translational research teams, compete successfully for grant support and provide novel insights into the causes, pathophysiology and treatment of pediatric diseases that affect the Nation's children.

描述（由申请人提供）：多个障碍，包括，1）缺乏用于研究培训和实施的强大基础设施，在小儿输血医学和血液学中进行高质量和变革性研究的进行； 2）职业中期和高级调查员短缺作为研究导师； 3）需要多学科翻译方法来回答关键的临床问题； 4）尽管有疾病和疾病的少数少数少数人数不成比例，但临床和转化调查人员在少数群体状况和性别方面缺乏多样性，但可能会受益于此类调查。我们使用此应用程序提出了一项高度协作和多学科的机构间计划，该计划是针对未来科学家在儿科输血医学和血液学领域的培训，这将解决这些障碍。它将重点介绍有关血液学，心血管和肺部疾病，输血和移植的诊断和临床管理的临床和转化奖学金。该计划，小儿血液学和输血医学多学科研究培训奖（PHTMMRT）的长期目标是为学术领导和独立资助的研究职业做好不同背景的学员准备。该计划中的每个学员都将在乔治华盛顿大学医学与健康科学学院（GWU）完成临床和转化科学硕士学位（MSCTR），并将在多学科指导团队的共同监督下设计，实施和完成一项研究项目。三年计划完成后，每个受训者将至少在一次国家研究会议上介绍其数据，并提交并提交了一个或多个适合外部同行评审出版物的手稿，并向NIH或同等资金来源提交了外部赠款申请。该计划将由具有独特和互补的临床背景和研究专业知识的两位高素质和NIH资助的首席研究人员/计划主管（PIS/PDS）监督。他们将得到9位儿童国家教职员工及其附属GWU医学与健康科学学院（GWU）的支持，并由9位外部导师是具有凝结，输血医学，移植，镰状细胞病和血管生物学专业知识的研究科学家。多样性增强官，一名完整的教授和资助的调查员，将协助招募少数民族，残疾或处境不利的申请人以及妇女。最后，由6名由NIH资助的全国性输血医学和血液学领导者组成的外部咨询委员会将通过既定的职业指导计划在PHTMMRT计划的发展以及受训者的进步方面提供年度反馈和指导。 PHTMMRT计划将通过利用儿童国民（CNMC）多个多重和现有的优势来直接解决上述每个障碍，与邻近的研究机构（包括NIH，美国红十字会，FDA，FDA和霍华德大学医学学院）的合作优势，提供了出色的培训机会。这些优势包括1.a）从机械调查到卫生服务研究的整个范围内的转化和临床科学家的可用性； 1.B）一群经验丰富的NIH资助教师，他们与我们的外部导师一起提供了无与伦比的核心设施和研究培训； 2）我们大型的当地学者和其他学员社区，通过学员委员会，他们将在团队科学中提供合作，正式和非正式的跨学科学习机会； 3）我们强大的CTSA资助基础设施用于支持受训人员研究，包括临床和转化研究的MS； 4）我们长期致力于招募和培训来自代表性不足的少数民族或妇女的各种临床学科的调查人员。我们的跨学科，机构间导师将培训四名未来的小儿血液学和输血医学学术领导者，他们将领导临床和转化研究团队，成功地竞争授予支持，并提供对影响国家儿童的儿童生理学和病理生理学和治疗的新见解。