Gene/environment Susceptibility Iceland-Ocular Component

年龄基因/环境易感性-雷克雅未克研究（AGES）是一项横断面研究，通过重新检查1967年建立的冰岛雷克雅未克队列，评估候选基因的相对贡献和老年常见疾病的相互关系。这是冰岛心脏协会（IHA）和NIA之间的合作项目（根据合同机制资助）。目标人群是9，500名幸存成员（现在年龄在65-94岁之间），其中多达8，000人将在三次诊所访问中接受全面的诊所检查，1，500名非常年老或身体虚弱的人将在家中接受修改后的检查。可获得来自队列先前检查的详细健康和医疗信息以及储存的血清和其他生物标本。本研究关注的表型包括：神经认知疾病（痴呆、抑郁、神经感觉特征）、心血管健康（动脉粥样硬化、动脉扩张性、心室和瓣膜疾病）、肌肉骨骼疾病（脊柱和髋关节骨质疏松、关节骨关节炎、力量和功能）以及身体组成和代谢疾病（肥胖、肌肉减少症、高血糖症、糖尿病）。 NEI在研究中增加了眼部部分，需要进行视力评估，并通过双眼散瞳拍摄视网膜眼底和黄斑区的数字图像。感兴趣的是能够估计AMD和糖尿病视网膜病变表型的患病率，并测试关于这些条件的候选基因的假设，以及检查视网膜微血管变化与其他非眼部表型和与它们相关的候选基因之间的相互关系。2002年9月开始入组主研究。三次研究访视同时进行，三次访视中的每一次均计划在约两个月的时间窗内进行。在2002年12月的第三次研究访视中增加了眼部部分。 截至2005年7月，已经检查了4 323人的眼睛。数据收集计划持续到2006日历年，对累积的眼部数据进行密集的质量控制监测。 一个全面的中期分析数据集，其中包括从第一批2,300名登记的AGES研究参与者中收集的所有措施，定于今年晚些时候（2005年）提供。

The Age Gene/Environment Susceptibility -Reykjavik Study (AGES) is a cross-sectional study to assess the relative contribution of candidate genes and interrelationships of diseases common in old age by reexamining the Icelandic Reykjavik Cohort established in 1967. This is a collaborative project between the Icelandic Heart Association (IHA) and the NIA (funded under a contract mechanism). The target population is the 9,500 surviving members (now ages 65-94) of whom up to 8,000 will undergo a complete clinic examination over three clinic visits and 1,500 of the very old or physically frail will undergo a modified examination in their home. Detailed health and medical information from previous examinations of the cohort as well as stored serum and other biologic specimens are available. Phenotypes of interest for the study include: neurocognitive conditions (dementia, depression, neurosensory profile), cardiovascular health (atherosclerosis, arterial distensibility, ventricular and valvular disease), musculoskeletal conditions (spine and hip osteoprosis, joint osteoarthritis, strength and function), and body composition and metabolic disease (obesity, sarcopenia, hyperglycemia, diabetes). The NEI has added an ocular component to the study which entails an acuity assessment and capturing digital images of the fundus and macular regions of the retina as taken through dilated pupils in both eyes. Of interest is the ability to estimate the prevalence of AMD and diabetic retinopathy phenotypes and to test hypotheses about candidate genes for these conditions, as well as to examine interrelationships between retinal microvascular changes in conjunction with other non-ocular phenotypes and the candidate genes associated with them. Enrollment into the main study began in September 2002. The three study visits are run concurrently and each of the three visits is scheduled to occur within an approximately two month window. The ocular component was added to the third study visit in December 2002. As of July 2005, the eyes of 4,323 people have been examined. Data collection is planned to last through calendar year 2006, and intensive quality control monitoring of accruing ocular data are on-going. A comprehensive interim analysis data set containing all measures collected from the first 2,300 enrolled AGES study participants is slated to be available in later this year (in 2005).