Multi-ethnic Study Of Atherosclerosis - Vision Component

动脉粥样硬化的多种族研究(MESA)是一项多中心的队列研究，对年龄在45-84岁之间患有亚临床心血管疾病的6500名高加索人、西班牙人、非裔美国人和亚裔美国人的人群样本进行了长达10年的跟踪调查，以确定预测进展为显性心血管疾病的因素。MESA研究由NHLBI赞助，并根据合同提供资金。台眼部分(折射和眼底摄影)于2002年9月在第二次台面检查时开始。其目的是记录黄斑变性和糖尿病视网膜病变的视网膜微血管改变的存在和严重程度(从数字视网膜照片读取)，并描述它们与大血管疾病的横断面和纵向测量的相互关系，包括高血压、糖尿病、炎症、内皮功能障碍和脑结构和功能的各种标志。视力/客观屈光成分将使我们能够根据性别和种族估计视力损害，确定通过更好的屈光矫正可以减少损害的程度，并将视力损害与眼底摄影结果相关联。

The Multi-Ethnic Study of Atherosclerosis (MESA) is a multicenter, cohort study in which a population-based sample of 6,500 Caucasian, Hispanic, African-American and Asian-American men and women aged 45-84 with subclinical cardiovascular disease are followed for 10 years to identify factors predictive of progression to overt cardiovascular disease. The MESA study is sponsored by NHLBI and is funded under contract. The MESA-EYE component (refraction and fundus photography) began in September 2002 at the second MESA visit. The aims are to document the presence and severity of retinal microvascular changes (as read from digital retinal photos) indicative of macular degeneration and diabetic retinopathy and to describe their interrelationships with cross-sectional and longitudinal measures of macrovascular disease, including hypertension, diabetes, inflammation, endothelial dysfunction, and various markers of brain structure and function. The visual acuity/objective refraction component will allow us to estimate visual impairment by sex and ethnicity, determine the degree to which impairment could be reduced with better refractive correction, and to correlate visual impairment with fundus photography findings.