Age, Gene/environment Susceptibility Study In Iceland -

年龄基因/环境易感性研究(AGES)是一项横断面研究，旨在通过重新审查1967年建立的冰岛雷克雅未克队列，评估候选基因的相对贡献和老年常见病的相互关系。这是冰岛心脏协会(IHA)和NIA(根据合同机制提供资金)之间的合作项目。目标人群是9500名幸存成员(现为65-94岁)，其中8000人将在三次诊所就诊后接受全面诊所检查，1500名非常年老或身体虚弱的人将在家中接受改装检查。从以前的队列检查以及储存的血清和其他生物标本中可以获得详细的健康和医学信息。这项研究感兴趣的表型包括：神经认知状况(痴呆症、抑郁症、神经感觉状况)、心血管健康状况(动脉粥样硬化、动脉扩张性、脑室和瓣膜疾病)、肌肉骨骼状况(脊柱和髋部骨质疏松症、关节骨关节炎、力量和功能)以及身体成分和代谢疾病(肥胖、骨质疏松症、高血糖、糖尿病)。NEI在这项研究中增加了一个眼睛部分，这需要进行视力评估，并通过双眼扩大的瞳孔捕捉视网膜眼底和黄斑区域的数字图像。人们感兴趣的是评估AMD和糖尿病视网膜病变表型的患病率，检验这些疾病的候选基因的假说，以及检查视网膜微血管变化与其他非眼部表型和与它们相关的候选基因之间的相互关系。2002年9月开始注册参加主要研究。 在2003财政年度，最终确定了眼科部件的规程，编写了培训材料，并制定了质量控制计划。2002年11月，IHA工作人员接受了关于如何获得视力数据和视网膜图像的培训。眼睛部分被添加到2002年12月的第三次研究访问中。截至2003年8月，有1053人参与了眼部手术。正在进行数据收集和监测。数据管理活动已经开始。

The Age Gene/Environment Susceptibility Study (AGES) is a cross-sectional study to assess the relative contribution of candidate genes and interrelationships of diseases common in old age by reexamining the Icelandic Reykjavik Cohort established in 1967. This is a collaborative project between the Icelandic Heart Association (IHA) and the NIA (funded under a contract mechanism). The target population is the 9,500 surviving members (now ages 65-94) of whom 8,000 will undergo a complete clinic examination over three clinic visits and 1,500 of the very old or physically frail will undergo a modified examination in their home. Detailed health and medical information from previous examinations of the cohort as well as stored serum and other biologic specimens are available. Phenotypes of interest for the study include: neurocognitive conditions (dementia, depression, neurosensory profile), cardiovascular health (atherosclerosis, arterial distensibility, ventricular and valvular disease), musculoskeletal conditions (spine and hip osteoprosis, joint osteoarthritis, strength and function), and body composition and metabolic disease (obesity, sarcopenia, hyperglycemia, diabetes). The NEI has added an ocular component to the study which entails an acuity assessment and capturing digital images of the fundus and macular regions of the retina as taken through dilated pupils in both eyes. Of interest is the ability to estimate the prevalence of AMD and diabetic retinopathy phenotypes and to test hypotheses about candidate genes for these conditions, as well as to examine interrelationships between retinal microvascular changes in conjunction with other non-ocular phenotypes and the candidate genes associated with them. Enrollment into the main study began in September 2002. In fiscal year 2003 the protocols for the ocular components were finalized, training materials prepared, and a quality control plan developed. In November 2002 IHA staff received training on how to obtain the vision data and the retinal images. The ocular component was added to the third study visit in December 2002. As of August 2003, 1053 people participated in the ocular component. Data collection and monitoring is on-going. Data management activities have begun.