Multi-ethnic Study Of Atherosclerosis - Vision Component

动脉粥样硬化的多种族研究 - 视觉成分

• 批准号: 6826968
• 负责人: MARY FRANCES COTCH
• 金额: --
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6826968
• 关键词: African American; Asian Americans; Hispanic Americans; atherosclerosis; caucasian American; clinical research; diabetes mellitus; diabetic retinopathy; epidemiology; eye fundus photography; gender difference; human middle age (35-64); human old age (65+); human subject; hypertension; inflammation; longitudinal human study; macular degeneration; racial /ethnic difference; retina circulation disorder; vision disorders; visual perception

The Multi-Ethnic Study of Atherosclerosis (MESA) is a multicenter, cohort study in which a population-based sample of 6,814 Caucasian, Hispanic, African-American and Asian-American men and women aged 45-84 with subclinical cardiovascular disease are followed for 10 years to identify factors predictive of progression to overt cardiovascular disease. The MESA study is sponsored by NHLBI and is funded under contract. Dr. Cotch is a collaborator in the MESA-EYE component (refraction and fundus photography). Part of the second MESA visit and beginning in September 2002, the aims of the ocular component are to document the presence and severity of retinal microvascular changes (as interpreted from digital retinal photos) indicative of macular degeneration and diabetic retinopathy, as well as to describe their interrelationships with cross-sectional and longitudinal measures of microvascular and macrovascular systemic disease. The visual acuity/objective refraction component will allow us to estimate visual impairment by sex and ethnicity, determine the degree to which visual impairment could be reduced with better refractive correction, and correlate visual findings with retinal pathology. During this fiscal year, quality control procedures were developed and implemented. Data management activites are underway. As of August 2003, 4736 MESA participants completed the ocular component. The projected completion of the second MESA visit for all members of the MESA cohort is scheduled to occur next fiscal year. Data are projected to be available for analytic purposes a few months thereafter.

动脉粥样硬化多种族研究 (MESA) 是一项多中心队列研究，对 6,814 名 45-84 岁患有亚临床心血管疾病的白人、西班牙裔、非裔美国人和亚裔美国男性和女性进行了为期 10 年的跟踪研究，以确定预测明显心血管疾病进展的因素。 MESA 研究由 NHLBI 赞助并根据合同提供资金。 Cotch 博士是 MESA-EYE 组件（验光和眼底摄影）的合作者。第二次 MESA 访问的一部分从 2002 年 9 月开始，眼科部分的目的是记录表明黄斑变性和糖尿病视网膜病变的视网膜微血管变化（根据数字视网膜照片解释）的存在和严重程度，以及描述它们与微血管和大血管系统疾病的横截面和纵向测量的相互关系。视敏度/客观屈光成分将使我们能够根据性别和种族估计视力障碍，确定通过更好的屈光矫正可以减少视力障碍的程度，并将视觉结果与视网膜病理相关联。 在本财年中，制定并实施了质量控制程序。数据管理活动正在进行中。截至 2003 年 8 月，4736 名 MESA 参与者完成了眼科部分。 MESA 队列所有成员的第二次 MESA 访问预计将于下一财年完成。预计数据将在几个月后用于分析目的。