Age, Gene/environment Susceptibility Study In Iceland -

年龄基因/环境易感性-雷克雅未克研究(AGES)被设想为一项横断面研究，通过重新审查1967年建立的冰岛雷克雅未克队列，评估候选基因的相对贡献和老年常见疾病的相互关系。这是冰岛心脏协会(IHA)和NIA(根据合同机制提供资金)之间的合作项目。其他NIH研究所(NIDCD、NHLBI、NINDS和NEI)也增加了组件。 当这项研究在2001年构思时，目标人群是雷克雅未克研究队列中大约9500名幸存成员(当时年龄在65岁至94岁之间)，其中多达8000人将在三次诊所就诊后接受全面临床检查，1500名高龄或身体虚弱的人将在家中接受修改后的检查。2002年9月开始注册参加主要研究。需要三次单独的访问才能完成广泛的研究测试。三次考察访问是同时进行的，每一次访问都计划在大约两个月的窗口内进行。2002年12月，由于财政限制，NEI增加了一个眼科部分，该研究在招募了大约5,500人后，于2006年初结束了招募。 从以前的队列检查以及储存的血清和其他生物标本中可以获得详细的健康和医学信息。这项研究感兴趣的表型包括：神经认知状况(痴呆症、抑郁症、神经感觉状况)、心血管健康状况(动脉粥样硬化、动脉扩张性、脑室和瓣膜疾病)、肌肉骨骼状况(脊柱和髋部骨质疏松症、关节骨关节炎、力量和功能)以及身体成分和代谢疾病(肥胖、骨质疏松症、高血糖、糖尿病)。 眼睛部分包括视力评估和通过双眼扩大的瞳孔拍摄的视网膜眼底和黄斑区的数字图像。人们感兴趣的是评估AMD和糖尿病视网膜病变表型的患病率，检验这些疾病的候选基因的假说，以及检查视网膜微血管变化与其他非眼部表型和与它们相关的候选基因之间的相互关系。 正在进行广泛的数据清理工作；正在准备数据文件和文件；已经完成了对选定候选人的第一轮单核苷酸多态性基因分型；初步数据分析正在进行中。

The Age Gene/Environment Susceptibility -Reykjavik Study (AGES) was conceived as a cross-sectional study to assess the relative contribution of candidate genes and interrelationships of diseases common in old age by reexamining the Icelandic Reykjavik Cohort established in 1967. This is a collaborative project between the Icelandic Heart Association (IHA) and the NIA (funded under a contract mechanism). Other NIH Institutes (NIDCD, NHLBI, NINDS, and NEI) have added components also. When the study was conceived in 2001, the target population was to be the roughly 9,500 surviving members of the Reykjavik Study Cohort (then ages 65-94) of whom up to 8,000 would undergo a complete clinic examination over three clinic visits and 1,500 of the very old or physically frail would undergo a modified examination in their home. Enrollment into the main study began in September 2002. Three separate visits were required to complete the extensive battery of study testing. The three study visits were run concurrently and each of the three visits was scheduled to occur within an approximately two month window. In December 2002, the NEI added an ocular component Due to fiscal constraints, the study ended recruitment in early 2006 after recruiting approximately 5,500 individuals. Detailed health and medical information from previous examinations of the cohort as well as stored serum and other biologic specimens are available. Phenotypes of interest for the study include: neurocognitive conditions (dementia, depression, neurosensory profile), cardiovascular health (atherosclerosis, arterial distensibility, ventricular and valvular disease), musculoskeletal conditions (spine and hip osteoprosis, joint osteoarthritis, strength and function), and body composition and metabolic disease (obesity, sarcopenia, hyperglycemia, diabetes). The eye component included an acuity assessment and capturing digital images of the fundus and macular regions of the retina as taken through dilated pupils in both eyes. Of interest is the ability to estimate the prevalence of AMD and diabetic retinopathy phenotypes and to test hypotheses about candidate genes for these conditions, as well as to examine interrelationships between retinal microvascular changes in conjunction with other non-ocular phenotypes and the candidate genes associated with them. Extensive data cleaning efforts are underway; data file and documentation are under preparation; an initial round of genotyping SNPS for selected candidates has been completed; preliminary data analyses are on-going.