MESA Family - Ocular Component

梅萨家族研究旨在应用最先进的基因分型和遗传分析方法，通过研究参与NHLBI申办的多种族动脉粥样硬化研究（MESA-父母）的兄弟姐妹和选定的其他家庭成员，来描述动脉粥样硬化和其他心血管疾病亚临床指标的遗传基础。梅萨家族研究由NHLBI资助，主要研究者是Cedars-Sinai医学中心的杰罗姆罗特。除了固定的现场中心，该研究还涉及一个协调中心，一个中心实验室，两个遗传分析中心，以及计算机断层扫描，超声和视网膜摄影的阅读中心。梅萨系列采用与母梅萨研究中使用的相同的眼部方案来评估视力和视网膜病理学。 梅萨家族的主要目标包括确定450个西班牙裔美国人和450个非洲裔美国人的同胞，并进行表型分析;在这900个同胞中进行10 cM全基因组搜索和连锁分析，以确定可能包含导致心血管疾病变异的基因的区域。（和眼）表型;以及对至少3个，000例梅萨指数病例有待调查（或先前确定的试验）候选基因，并评估它们在参与母体梅萨研究的不同种族群体中的作用。 2004年5月开始招募梅萨家庭成员，目前仍在进行中。截至2004年8月，招募了161个家系。目前正在鉴定可能的候选基因。

The MESA Family study is designed to apply state-of-the-art genotyping and genetic analysis methodologies to delineate the genetic basis underlying atherosclerosis and other subclinical measures of cardiovascular disease by studying the siblings and selected other family members of a subset of individuals who participated in the NHLBI-sponsored Multi-Ethnic Study of Atherosclerosis (MESA-Parent). The MESA Family study is funded as a grant by NHLBI and the Principal Investigator is Jerome Rotter at Cedars-Sinai Medical Center. In addition to fix field centers, the study involves a Coordinating Center, a Central Laboratory, two Genetic Analysis Center, and Reading Centers for Computed Tomography, Ultrasound and Retinal Photography. The same ocular protocols for assessing vision and retinal pathology as those used in the parent MESA Study are employed for MESA Family. The main objectives for the MESA Family include the ascertainment and phenotyping of 450 Hispanic American and 450 African American sibships; a 10cM genome-wide search and linkage analysis in these 900 sibships to identify regions likely to contain genes contributing to variation in the cardiovascular (and ocular) phenotypes; and the conduct of genetic association analyses on data from at least 3,000 MESA index cases to investigate (or test previously identified) candidate genes and to evaluate their role of the candidate genes within the different ethnic groups participating in the parent MESA study. Recruitment of MESA Family sibships began in May 2004 and is on-going. As of August 2004, 161 pedigrees were recruited. The identification of possible candidate genes of interest is underway.