Multi-ethnic Study Of Atherosclerosis - Vision Component

动脉粥样硬化的多种族研究(MESA)是一项多中心的队列研究，对6814名年龄在45-84岁之间患有亚临床心血管疾病的高加索人、西班牙人、非裔美国人和亚裔美国人的人群样本进行了长达10年的跟踪调查，以确定预测进展为显性心血管疾病的因素。MESA研究由NHLBI赞助，并根据合同提供资金。科奇博士是台眼部分(屈光和眼底摄影)的合作者。 眼睛部分被纳入第二次梅萨访问，2002年9月至2003年12月期间有6235人参加。眼睛部分的目的是记录表明黄斑变性和糖尿病视网膜病变的视网膜微血管变化的存在和严重程度(从数字视网膜照片中解释)，并描述它们与临床、成像方式或生物实验室测量方法定义的微血管和大血管系统疾病的横断面和纵向测量的相互关系。视力/客观屈光成分的设计是为了让我们能够根据性别和种族来估计视力损害，确定通过更好的屈光矫正可以减少视觉损害的程度，并将视觉发现与视网膜病理相关联。 眼部数据正在与数据协调中心一起进行清理。2004年，提交了几份手稿提案，并由MESA研究领导批准。在研究调查人员获得数据后(可能发生在2005年)，将继续进行分析。

The Multi-Ethnic Study of Atherosclerosis (MESA) is a multicenter, cohort study in which a population-based sample of 6,814 Caucasian, Hispanic, African-American and Asian-American men and women aged 45-84 with subclinical cardiovascular disease are followed for 10 years to identify factors predictive of progression to overt cardiovascular disease. The MESA study is sponsored by NHLBI and is funded under contract. Dr. Cotch is a collaborator in the MESA-EYE component (refraction and fundus photography). The ocular component was integrated into the second MESA visit and 6235 people participated between September 2002 and December 2003. The aims of the ocular component are to document the presence and severity of retinal microvascular changes (as interpreted from digital retinal photos) indicative of macular degeneration and diabetic retinopathy, as well as to describe their interrelationships with cross-sectional and longitudinal measures of microvascular and macrovascular systemic disease as defined clinically, by imaging modality, or by analysis of biological laboratory measures. The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, determine the degree to which visual impairment could be reduced with better refractive correction, and correlate visual findings with retinal pathology. The ocular data are being cleaned in conjunction with the data coordinating center. In 2004, several manuscript proposals have been submitted and approved by the MESA study leadership. After the data become available to the study investigators (likely to occur in 2005), analysis will proceed.