Age, Gene/environment Susceptibility Study In Iceland

冰岛的年龄、基因/环境易感性研究

• 批准号: 6968591
• 负责人: MARY FRANCES COTCH
• 金额: --
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6968591
• 关键词: Scandinavian country; aging; atherosclerosis; body composition; diabetic retinopathy; eye disorder; gene environment interaction; genetic susceptibility; human old age (65+); human subject; macular degeneration; osteoarthritis; phenotype; sarcopenia; visual perception

The Age Gene/Environment Susceptibility Study (AGES) is a cross-sectional study to assess the relative contribution of candidate genes and interrelationships of diseases common in old age by reexamining the Icelandic Reykjavik Cohort established in 1967. This is a collaborative project between the Icelandic Heart Association (IHA) and the NIA (funded under a contract mechanism). The target population is the 9,500 surviving members (now ages 65-94) of whom 8,000 will undergo a complete clinic examination over three clinic visits and 1,500 of the very old or physically frail will undergo a modified examination in their home. Detailed health and medical information from previous examinations of the cohort as well as stored serum and other biologic specimens are available. Phenotypes of interest for the study include: neurocognitive conditions (dementia, depression, neurosensory profile), cardiovascular health (atherosclerosis, arterial distensibility, ventricular and valvular disease), musculoskeletal conditions (spine and hip osteoprosis, joint osteoarthritis, strength and function), and body composition and metabolic disease (obesity, sarcopenia, hyperglycemia, diabetes). The NEI has added an ocular component to the study which entails an acuity assessment and capturing digital images of the fundus and macular regions of the retina as taken through dilated pupils in both eyes. Of interest is the ability to estimate the prevalence of AMD and diabetic retinopathy phenotypes and to test hypotheses about candidate genes for these conditions, as well as to examine interrelationships between retinal microvascular changes in conjunction with other non-ocular phenotypes and the candidate genes associated with them. Enrollment into the main study began in September 2002. The three study visits are run concurrently and each of the three visits is scheduled to occur within an approximately two month window. The ocular component was added to the third study visit in December 2002. As of August 2004, the eyes of 2,973 people have been examined. Data collection and intensive quality control monitoring of accruing ocular data are on-going. A comprehensive interim analysis data set containing all measures from approximately 2,400 AGES study participants taken at each of the three study visits data is slated to be available in Fiscal Year 2005.

年龄基因/环境易感性研究（AGES）是一项横断面研究，通过重新检查1967年建立的冰岛雷克雅未克队列，评估候选基因的相对贡献和老年常见疾病的相互关系。这是冰岛心脏协会（IHA）和NIA（在合同机制下资助）之间的合作项目。目标人群是9500名幸存的成员（现在年龄在65-94岁之间），其中8000人将在三次诊所访问中接受完整的诊所检查，1500名年老体弱的人将在家中接受修改后的检查。从以前的队列检查以及储存的血清和其他生物标本中获得详细的健康和医学信息。该研究关注的表型包括：神经认知状况（痴呆、抑郁、神经感觉状况）、心血管健康（动脉粥样硬化、动脉扩张性、心室和瓣膜疾病）、肌肉骨骼状况（脊柱和髋关节骨质疏松、关节骨关节炎、力量和功能）、身体组成和代谢疾病（肥胖、肌肉减少症、高血糖症、糖尿病）。NEI在研究中增加了眼部成分，需要进行视力评估，并通过双眼瞳孔放大拍摄眼底和视网膜黄斑区域的数字图像。我们感兴趣的是评估AMD和糖尿病视网膜病变表型的患病率，测试这些疾病的候选基因的假设，以及检查视网膜微血管变化与其他非眼部表型和与之相关的候选基因之间的相互关系的能力。主要研究的登记于2002年9月开始。这三次研究访问是同时进行的，每次访问都安排在大约两个月的窗口内进行。在2002年12月的第三次研究访问中增加了眼部成分。