Cell Migration Consortium

迁移是许多不同现象的关键过程，包括胚胎发育、肿瘤的形成和扩散、免疫反应中的白细胞募集和伤口修复。阐明细胞迁移的机制是一项艰巨的智力挑战，因为它由几个必须在空间和时间上协调的复杂的分子和细胞过程组成。对细胞迁移过程的充分理解需要一种跨学科的方法，这种方法将不同的专家与技能结合起来，为问题带来新的技术和智力解决方案。尽管移民研究在调查人员和知识方面都在快速增长，但进展很快就会受到一系列即将到来的智力和技术障碍的制约。我们建议利用大规模合作项目倡议来应对当前阻碍尚未完成的细胞迁移工作取得进展的障碍所带来的机遇和挑战。该计划的核心是创建一个高度互动的多学科研究联盟，该联盟由在黏附和细胞迁移领域拥有杰出成就的核心研究人员组成。该计划的核心是创建一个高度互动的多学科研究联盟，成员包括在黏附和细胞迁移领域拥有杰出成就的核心研究人员，从其他学科带来所需技术和专业知识的合作者，例如数学建模结构、成像、生物材料，并得到支持将其专业知识应用于迁移问题，最后是顾问，他们提供关于关键研究领域的建议和信息，以提高联盟的目标。该联盟的一个主要目标是开发克服细胞迁移研究面临的障碍所需的新技术。这将通过在核心调查员的指导下支持五项创新的发展研究举措(被指定为“发展核心”)来实现。蛋白质组学和基因组学核心将确定促进细胞迁移的基因和基因产品的完整体系；结构核心将在宏观和原子水平上分析大型超分子粘合组件的组织；信号核心将寻求新的方法来检测信号分子在空间和时间上的激活状态；转基因和基因敲除核心将创建具有转基因迁移机制的细胞和小鼠模型；建模核心将通过网络开发组件迁移过程和信号转导的定量分析和建模机制。此外，该联盟将通过包括质谱学、生物材料、蛋白质生产和分析以及细胞成像在内的关键支持设施，支持关键技术和技术开发。最后，财团将提供基础设施，以支持财团的行政需要，通过视频电信、生物信息学、数据和信息传播以及财团所有项目共有的技术资源促进互动。

Migration is a pivotal process in many diverse phenomena including embryonic development, tumor formation and spread, leukocyte recruitment during immune responses, and wound repair. Elucidating the mechanisms underlying cell migration presents a formidable intellectual challenge since it is comprised of several complex molecular and cellular processes that must be coordinated in both space and time. A full comprehension of the process of cell migration requires an interdisciplinary approach that combines diverse specialists with skills to bring novel technical and intellectual solutions to the problem. While migration research is undergoing rapid growth in both investigators and knowledge, progress will soon by restrained by an approaching set of intellectual and technological barriers. We propose using the Large Scale Cooperative Project initiative to address the opportunities and overcome the challenges posed by the present barriers to progress in outstanding cell migration. At the center of the initiative is a plan to create a highly interactive, multi-disciplinary research Consortium comprised of Core Investigators with outstanding records of accomplishment in the field of adhesion and cell migration. At the center of the initiative is a plan to create a highly interactive, multi-disciplinary research Consortium comprised of Core Investigators with outstanding records of accomplishment in the field of adhesion and cell migration, collaborators who bring needed technology and expertise from other disciplines, e.g., mathematical modeling structure, imaging, biomaterials, and are supported to apply their expertise to the migration problem, and finally consultants, who provide advice and information on critical areas of research need to enhance the goals of the Consortium. A major objective of the Consortium is to develop new technologies that are needed to over come the barriers that face cell migration research. This will be accomplished by supporting five innovative, developmental research initiatives (designated "Development Cores") under the direction of the Core Investigators. The Proteomics and Genomics Core will determine the complete repertoire of genes and gene products that contribute to cell migration; the Structure Core will analyze the organization of large, supramolecular adhesive assemblies at the macro and atomic level, the Signaling Core will seek novel approaches to the detection of activated states of signaling molecules in space and time; the Transgenic and Knockout Core will create cells and mouse models with genetically altered migration machinery; the Modeling Core will develop quantitative assays and modeling mechanisms of component migratory processes and signal transduction through networks. In addition, the Consortium will support critical technologies and technology development through key Support Facilities, including mass spectrometry, biomaterials, protein production and analysis and cell imaging. Finally, the Consortium will provide infrastructure to support the administrative needs of the Consortium, promote interaction through video telecommunications, bioinformatics, data and information dissemination and the technology resources that are common to all of the Consortium projects.