Project 6: Characterization of Exposures of Urban and Rural Cohorts to

项目 6：城乡人群暴露特征描述

• 批准号: 7106955
• 负责人: Peter S Thorne
• 金额: $ 36.33万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7106955
• 关键词: adolescence (12-20); air pollution; air sampling /monitoring; atmosphere /weather; blood tests; body physical activity; children; diet; disease /disorder model; disease /disorder proneness /risk; environmental exposure; geographic difference; halobiphenyl /halotriphenyl compound; housing; human subject; longitudinal human study; model design /development; occupations; parents; questionnaires; rural area; schools; toxin metabolism; urban area

In Project 6 we will assess exposures to atmospheric PCBs among an urban cohort of children and their mothers in a heavily contaminated area where dredging and filling of PCB-laden sediments will occur during the study period. Exposures will be assessed through repeated air sampling over four years inside and outside of homes of subjects and at local schools and also through annual blood collection and assay for PCB congener profiles. These exposures will be compared to a rural site with the goal of characterizing atmospheric PCB exposures in high and low exposure residential cohorts. The urban site (East Chicago, IN) has a legacy of PCB contamination from intense past industrial activity whereas the rural site (Columbus Junction, IA) is without local sources of PCBs. The overall goal of the study is to establish airborne exposures of ethnically mixed populations, most and least at risk for adverse health outcomes from the more volatile PCBs. The following Specific Aims are proposed: Aim 1) Establish a residential cohort (n=108) in East Chicago. Aim 2) Establish a residential cohort (n=108) in Columbus Jet. Aim 3) Measure emissions and exposures of atmospheric PCBs at homes and schools over 4 years in the urban and rural cohorts. Aim 4) Gather demographic, residential, occupational, activity and dietary information from subjects by questionnaire. Aim 5) Analyze data from these cohorts and develop an exposure model for the atmospheric PCB congeners. The Indiana Harbor and Canal Dredging Project will place 4.5 million cubic yards of PCB-contaminated sediment into a confined disposal facility (CDF) located within 1/2 km of the middle and high school in East Chicago. Thus, we will perform air and blood monitoring of nearby residents before and during dredging and CDF filling and characterize determinants of exposure. Four primary hypotheses will be tested: H,: Residents of East Chicago have significantly higher exposures to atmospheric PCBs and (H2:) significantly higher blood levels of atmospheric PCB congeners than people living in rural Iowa. H3: In the urban cohort and the rural cohort, the body burden of the atmospheric PCB congeners of adolescent subjects are significantly correlated with those of their mothers. H4: Residents of East Chicago will experience significantly increased exposures to atmospheric PCBs and increased blood PCB concentrations associated temporally with the dredging of Indiana Harbor and placement of sediments in the confined disposal facility.

在项目6中，我们将评估城市儿童城市队列中大气PCB的暴露及其 在受污染的地区，母亲将在挖泥和填充PCB的沉积物中发生 研究期。暴露将通过在内部四年内重复进行空气采样来评估，并 在学科和当地学校的家庭之外，还通过年度血液收集和分析 PCB同源物概况。这些暴露将与农村地点进行比较，目的是表征 大气PCB暴露于高和低暴露住宅队列中。城市遗址（东部芝加哥，印第安纳州） 在过去的工业活动中具有PCB污染的遗产，而农村地区（哥伦布 IA交界处没有PCB的本地来源。该研究的总体目标是建立空降 种族混合种群的暴露，大多数和最少有不良健康结果的风险 PCB挥发性较大。提出了以下具体目标：目标1）建立住宅队列 （n = 108）在东芝加哥。目标2）在哥伦布喷气机中建立一个住宅队列（n = 108）。目标3）测量 在城市和农村的4年以上的房屋和学校的大气PCB的排放和暴露 同伙。目标4）从受试者那里收集人口，住宅，职业，活动和饮食信息 由问卷。目的5）分析来自这些队列的数据并为大气开发暴露模型 PCB同源物。印第安纳港和运河疏ed项目将在450万立方码处 PCB污染的沉积物进入位于中间和中间1/2公里以内的密闭处置设施（CDF） 东芝加哥的高中。因此，我们将对附近居民进行空气和血液监测和血液监测 在挖泥和CDF填充过程中，表征暴露的决定因素。四个主要假设将是 测试：H，：东芝加哥的居民对大气PCB和（H2 :)的暴露率明显更高 与居住在爱荷华州农村地区的人们相比，大气PCB同类物的血液水平要高得多。 H3：在 城市队列和农村队列，这是大气PCB的体重 与母亲的相关。 H4：东芝加哥的居民将体验 显着增加了对大气PCB的暴露量，并增加了与血液PCB相关的血液PCB浓度 随着印第安纳州港口的疏and，将沉积物放置在狭窄的处置设施中。