Project 6: Characterization of Exposures of Urban and Rural Cohorts to

在项目 6 中，我们将评估城市儿童群体及其孩子在大气中多氯联苯的暴露情况。 在严重污染地区的母亲们，在这些地区，将进行含多氯联苯沉积物的疏浚和填充。 学习期间。将通过四年内重复空气采样来评估暴露情况 在受试者的家外和当地学校以及通过每年的血液采集和化验 PCB同类配置文件。这些暴露将与农村地点进行比较，目的是表征 高暴露和低暴露居住人群中大气 PCB 暴露。城市场地（印第安纳州东芝加哥） 由于过去激烈的工业活动而遗留下来的多氯联苯污染，而农村地区（哥伦布 爱荷华州 Junction）没有本地多氯联苯来源。该研究的总体目标是建立机载 种族混合人群的暴露，最大和最小的不良健康结果风险 PCB 的挥发性越强。提出以下具体目标： 目标 1) 建立居住群体 (n=108) 位于东芝加哥。目标 2) 在 Columbus Jet 建立一个居住队列 (n=108)。目标 3) 测量 城乡家庭和学校4年大气中PCBs排放量和暴露量 队列。目标 4) 收集受试者的人口统计、居住、职业、活动和饮食信息 通过问卷调查。目标 5) 分析这些群体的数据并开发大气暴露模型 PCB同系物。印第安纳州港口和运河疏浚项目将铺设 450 万立方码 将受 PCB 污染的沉积物放入位于中部和中部 1/2 公里范围内的封闭处置设施 (CDF) 东芝加哥高中。因此，我们会在之前和之后对附近居民进行空气和血液监测。 在疏浚和 CDF 填充过程中，并描述暴露的决定因素。四个主要假设将是 测试：H,：东芝加哥居民对大气中多氯联苯的暴露明显较高（H2:) 与生活在爱荷华州农村的人们相比，血液中大气中多氯联苯同系物的含量显着升高。 H3：在 城市队列和农村队列，青少年受试者大气中PCB同系物的身体负担 与母亲的情况显着相关。 H4：东芝加哥居民将体验 显着增加大气中 PCB 的暴露量并增加相关的血液 PCB 浓度 暂时进行印第安纳港的疏浚并将沉积物放入密闭处置设施中。

In Project 6 we will assess exposures to atmospheric PCBs among an urban cohort of children and their mothers in a heavily contaminated area where dredging and filling of PCB-laden sediments will occur during the study period. Exposures will be assessed through repeated air sampling over four years inside and outside of homes of subjects and at local schools and also through annual blood collection and assay for PCB congener profiles. These exposures will be compared to a rural site with the goal of characterizing atmospheric PCB exposures in high and low exposure residential cohorts. The urban site (East Chicago, IN) has a legacy of PCB contamination from intense past industrial activity whereas the rural site (Columbus Junction, IA) is without local sources of PCBs. The overall goal of the study is to establish airborne exposures of ethnically mixed populations, most and least at risk for adverse health outcomes from the more volatile PCBs. The following Specific Aims are proposed: Aim 1) Establish a residential cohort (n=108) in East Chicago. Aim 2) Establish a residential cohort (n=108) in Columbus Jet. Aim 3) Measure emissions and exposures of atmospheric PCBs at homes and schools over 4 years in the urban and rural cohorts. Aim 4) Gather demographic, residential, occupational, activity and dietary information from subjects by questionnaire. Aim 5) Analyze data from these cohorts and develop an exposure model for the atmospheric PCB congeners. The Indiana Harbor and Canal Dredging Project will place 4.5 million cubic yards of PCB-contaminated sediment into a confined disposal facility (CDF) located within 1/2 km of the middle and high school in East Chicago. Thus, we will perform air and blood monitoring of nearby residents before and during dredging and CDF filling and characterize determinants of exposure. Four primary hypotheses will be tested: H,: Residents of East Chicago have significantly higher exposures to atmospheric PCBs and (H2:) significantly higher blood levels of atmospheric PCB congeners than people living in rural Iowa. H3: In the urban cohort and the rural cohort, the body burden of the atmospheric PCB congeners of adolescent subjects are significantly correlated with those of their mothers. H4: Residents of East Chicago will experience significantly increased exposures to atmospheric PCBs and increased blood PCB concentrations associated temporally with the dredging of Indiana Harbor and placement of sediments in the confined disposal facility.