The AESOP Study: Airborne Exposures to Semi-volatile Organic Pollutants

AESOP 研究：空气中半挥发性有机污染物的暴露

• 批准号: 10559691
• 负责人: Peter S Thorne
• 金额: $ 26.45万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-12 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10559691
• 关键词: Accounting; Adolescence; Adolescent; Air; American; Area; Back; Behavioral; Biological Markers; Biological Monitoring; Blood; Body Burden; Breast Feeding; Breathing; Chicago; Child; Chronic; Cohort Studies; Collaborations; Communities; Coupled; DNA; Data; Data Aggregation; Diet; Dietary Assessment; Dietary intake; Dose; Drug Kinetics; Eating; Enrollment; Environment; Environmental Health; Environmental Pollution; Excretory function; Exposure to; Family Study; Food; Freedom; Functional disorder; Funding; Health; Health Status; Home; Hormones; Human; Indiana; Individual; Indoor Air Pollution; Inflammation; Inhalation; Inhalation Exposure; Inhalation Toxicology; Iowa; Life Cycle Stages; Link; Location; Measurement; Measures; Metabolic syndrome; Metabolism; Midwestern United States; Modeling; Mothers; National Health Interview Survey; Occupational; Oral; Outcome; Oxidative Stress; Participant; Perinatal Exposure; Physiological; Policies; Polychlorinated Biphenyls; Production; Questionnaires; Reporting; Research; Resources; Risk; Risk Assessment; Risk Estimate; Risk Factors; Role; Route; Rural; Sampling; Schools; Serum; Source; Study Subject; Superfund; Surveys; Testing; Thyroid Hormones; Time; Toxic effect; Uncertainty; Urine; Volatilization; absorption; bilingualism; biobank; building materials; cohort; community based participatory research; community based research; community engagement; computerized tools; data de-identification; design; dietary; early detection biomarkers; ethnic diversity; experience; exposure route; food consumption; health data; indoor concentrations; innovation; insight; models and simulation; nanofiber; neurobehavioral; novel; pharmacokinetic model; physiologically based pharmacokinetics; placental transfer; pollutant; potential biomarker; predictive modeling; programs; racial diversity; recruit; remediation; research study; superfund chemical; uptake

SUMMARY: Project 3 – The AESOP Study The Iowa Superfund Research Program (ISRP) AESOP Study (Airborne Exposures to Semi-volatile Organic Pollutants) is a community-based participatory research study that assesses inhalation and dietary exposures to PCBs, PCB metabolites, and potential biomarkers among cohorts of adolescent children and their mothers in three Midwest U.S. communities. We previously reported that although intentional production of PCBs as legacy Superfund chemicals ended in the 1970s, production continues as building material byproducts. The AESOP Study identifies the determinants of PCB exposures, including dietary intake and airborne exposure levels indoors and outdoors. In the proposed new funding cycle, the AESOP Study will have an unparalleled opportunity to characterize the role of personal inhalation exposures to PCBs at home and in schools for their contribution to the exposure burden that could result in elevated risks for hormone disruption, metabolic syndrome, and neurobehavioral outcomes. The Specific Aims are: Aim 1: Collect and analyze demographic, residential, occupational, activity, dietary, and health data from AESOP Study participants. Aim 2: Characterize personal exposures to PCB congeners among children and their mothers and apportion exposures to inhalation and diet at the congener level. The study will analyze blood and urine for 209 PCBs and 74 metabolites as well as for biomarkers of thyroid hormone dysfunction, inflammation, and metabolic syndrome. Aim 3: Assess adolescent children’s time-integrated personal exposure to airborne PCBs. Aim 4: Model PCB congener exposures and body burdens; compare modeled and measured data. The study enjoys strong community support garnered through our Community Advisory Boards working with AESOP Study staff and the ISRP Community Engagement Core; this support will help facilitate these aims. The AESOP Study employs bilingual community-based field staff and has enrolled and followed 381 subjects in racially and ethnically diverse communities, providing new insights into airborne exposures and resulting body burdens. The AESOP Study provides human samples and data to other projects within the ISRP, providing enhanced relevance for those projects. De-identified data are widely shared with study participants, the scientific community, and stakeholders at EPA and ATSDR. The AESOP Study has already changed the prevailing views on how most Americans are exposed to PCBs. We have demonstrated that children have substantial exposure to PCB congeners from inhalation at school; their blood shows enrichment with inhaled lower- chlorinated congeners. This has important implications for children’s environmental health that the AESOP Study will further elucidate during the next five years.

摘要：项目 3 – AESOP 研究 爱荷华州超级基金研究计划 (ISRP) AESOP 研究（空气中半挥发性有机物暴露） 污染物）是一项基于社区的参与性研究，评估吸入和饮食暴露 青春期儿童及其母亲群体中的 PCB、PCB 代谢物和潜在生物标志物 在美国中西部的三个社区。我们之前报道过，尽管有意生产 PCB 传统的超级基金化学品于 20 世纪 70 年代结束，作为建筑材料副产品继续生产。这 AESOP 研究确定了 PCB 暴露的决定因素，包括饮食摄入量和空气传播暴露 室内和室外的水平。在拟议的新资助周期中，AESOP 研究将具有无与伦比的 有机会描述个人在家中和学校吸入多氯联苯的影响 增加暴露负担，可能导致激素紊乱、代谢紊乱的风险升高 综合征和神经行为结果。具体目标是： 目标 1：收集和分析人口统计数据， AESOP 研究参与者的居住、职业、活动、饮食和健康数据。目标 2：表征 儿童及其母亲对 PCB 同系物的个人接触情况以及对 PCB 同系物的接触情况分摊 吸入和饮食处于同类水平。该研究将分析血液和尿液中的 209 种多氯联苯和 74 种 代谢物以及甲状腺激素功能障碍、炎症和代谢综合征的生物标志物。 目标 3：评估青春期儿童接触空气中 PCB 的时间综合个人暴露情况。目标 4：PCB 模型 同类物暴露和身体负担；比较建模数据和测量数据。学习享受强 通过我们的社区咨询委员会与 AESOP 研究人员合作获得的社区支持，以及 ISRP 社区参与核心；这种支持将有助于促进这些目标的实现。 AESOP 研究 雇用双语社区现场工作人员，并已登记并跟踪了 381 名种族和种族方面的受试者 种族多元化的社区，为空气传播暴露和由此产生的身体负担提供新的见解。 AESOP 研究为 ISRP 内的其他项目提供人体样本和数据，从而提供增强的 与这些项目的相关性。去识别化数据与研究参与者、科学界广泛共享 以及 EPA 和 ATSDR 的利益相关者。 AESOP 研究已经改变了流行的观点 关于大多数美国人如何接触多氯联苯的看法。我们已经证明，孩子们有大量的 在学校因吸入多氯联苯同系物而接触；他们的血液显示出吸入较低浓度的 氯化同系物。这对儿童的环境健康具有重要影响，AESOP 研究将在未来五年内进一步阐明。