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PTSD and Drug Dependence: Neuroimaging of Reward Circui*

创伤后应激障碍（PTSD）和药物依赖：奖励循环的神经影像*

基本信息

批准号：
7466339
负责人：
IGOR ELMAN
金额：
$ 9.49万
依托单位：
MCLEAN HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-06-01 至 2009-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7466339
关键词：
Address Alcohols Anxiety Appendix Area Brain Categories Child Chronic Chronic stress Clinical Research Clinical Trials Cocaine Cocaine Dependence Collection Color Consumption Data Development Development Plans Disease Dose Drug Addiction Drug usage Emotional Experimental Psychology Face Functional Magnetic Resonance Imaging Functional disorder Gambling Instruction Letters Literature Methods Mind Minority Monitor Morphine Nucleus Accumbens Numbers Pattern Pharmaceutical Preparations Phase Post-Traumatic Stress Disorders Process Progress Reports Psychopharmacology Publications Research Research Design Resources Rewards Safety Score Severities Signal Transduction Statistically Significant Stimulus Stress Substance Use Disorder Substance of Abuse System Therapeutic Intervention Vertebrates Visual Woman Women&apos s Group addiction avoidance behavior conditioned fear design human subject indexing insight male neuroimaging pre-clinical reinforcer response reward circuitry social visual process visual processing

项目摘要

four pa.qes) ..................... 12 Other Biographical Sketches (Not to exceed four pages for each - See instructions)) ............................ 15 Resources ........................................................................................................................................................ 42 Research Plan Introduction to Revised Application (Notto exceed 3 pages) ................................................................................................................ Introduction to Supplemental Application (Not to exceed one page) ..................................................................................................... 48 A. Specific Aims ............................................................................ ._. ......................................................................................... 48 B. Background and Significance ................................................... .....|. ........................................................................................ I 57 C, Preliminary Studies/Progress Report/ _ (Items A-D: not to exceed 25 pages*) "_t Phase I Progress Report (SBIR/STTR Phase II ONLY) F SBIR/STTR Phase l: ltems A-D limited t¿15 pages I [3. Research Design and Methods ................................................ _ .......................................................................................... 62 E. Human Subjects .......................................................................................................................................................................... 73 Protection of Human Subjects (Required if Item 4 on the Face Page is marked "Yes") Inclusion of Women (Required if Item 4 on the Face Page is marked "Yes") ...................................................................... Inclusion of Minorities (Required if Item 4 on the Face Page is marked "Yes") .................................................................... Inclusion of Children (Required if Item 4 on the Face Page is marked "Yes") ...................................................................... Data and Safety Monitoring Plan (Required if Item 4 on the Face Page is marked "Yes" anda Phase I, II, or III clinical trial is proposed ............................................................................................................................................................... F. Vertebrate Animals ...................................................................................................................................................................... G. Literature Cited ............................................................................................................................................................................ 82 H. Consortium/Contractual Arrangements ....................................................................................................................................... I. Letters of Support (e.g., Consultants) ......................................................................................................................................... 96 J. Product Development Plan (SBIRISTTR Phase II and Fast-Track ONLY) ............................................................................... Checklist ........................................................................................................................................................... 102 Check if Appendix (Five collated sets. No page numbering necessary for Appendix.) Appendix is Included Appendices NO T PERMITTED for Phase I SBIR/S TTR unless specifically solicited. Number of publications and manuscdpts accepted for publication (not to exceed 10) Other items (list): Appendix I Color Plates of Figures in Preliminary Studies PHS 398 (Rev. 05/01) Page 3 Form Page 3

四。问 ) .....................12

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Mechanisms Underlying Unconscious Processing and Their Alterations in Post-traumatic Stress Disorder: Neuroimaging of Zero Monetary Outcomes Contextually Framed as "No Losses" vs. "No Gains".

DOI：
10.3389/fnins.2020.604867
发表时间：
2020
期刊：
Frontiers in neuroscience
影响因子：
4.3
作者：
Elman I;Upadhyay J;Lowen S;Karunakaran K;Albanese M;Borsook D
通讯作者：
Borsook D

Neurological soft signs in individuals with pathological gambling.

DOI：
10.1371/journal.pone.0060885
发表时间：
2013
期刊：
PloS one
影响因子：
3.7
作者：
Elman I;Gurvits TV;Tschibelu E;Spring JD;Lasko NB;Pitman RK
通讯作者：
Pitman RK

Yohimbine-induced amygdala activation in pathological gamblers: a pilot study.

DOI：
10.1371/journal.pone.0031118
发表时间：
2012
期刊：
PloS one
影响因子：
3.7
作者：
Elman I;Becerra L;Tschibelu E;Yamamoto R;George E;Borsook D
通讯作者：
Borsook D

Impaired reproduction of three-dimensional objects by cocaine-dependent subjects.

可卡因依赖者对三维物体的再现受损。

DOI：
10.1176/jnp.2008.20.4.478
发表时间：
2008
期刊：
The Journal of neuropsychiatry and clinical neurosciences
影响因子：
0
作者：
Elman,Igor;Chi,WonH;Gurvits,TamaraV;Ryan,ElizabethT;Lasko,NatashaB;Lukas,ScottE;Pitman,RogerK
通讯作者：
Pitman,RogerK

DOI：
10.1523/jneurosci.6709-10.2011
发表时间：
2011-03-09
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
0
作者：
Moulton EA;Elman I;Pendse G;Schmahmann J;Becerra L;Borsook D
通讯作者：
Borsook D