创伤后应激障碍（PTSD）和药物依赖：奖励循环的神经影像*-猫眼课题宝

创伤后应激障碍（PTSD）和药物依赖：奖励循环的神经影像*

批准号：

7466339

负责人：

IGOR ELMAN

金额：

$9.49万

依托单位：

MCLEAN HOSPITAL

依托单位国家：

美国

项目类别：

财政年份：

2004

资助国家：

美国

项目状态：

已结题

起止时间：

2004-06-01 至 2009-05-31

来源：

https://reporter.nih.gov/project-details/7466339

关键词：

Address Alcohols Anxiety Appendix Area Brain Categories Child Chronic Chronic stress Clinical Research Clinical Trials Cocaine Cocaine Dependence Collection Color Consumption Data Development Development Plans Disease Dose Drug Addiction Drug usage Emotional Experimental Psychology Face Functional Magnetic Resonance Imaging Functional disorder Gambling Instruction Letters Literature Methods Mind Minority Monitor Morphine Nucleus Accumbens Numbers Pattern Pharmaceutical Preparations Phase Post-Traumatic Stress Disorders Process Progress Reports Psychopharmacology Publications Research Research Design Resources Rewards Safety Score Severities Signal Transduction Statistically Significant Stimulus Stress Substance Use Disorder Substance of Abuse System Therapeutic Intervention Vertebrates Visual Woman Women&apos s Group addiction avoidance behavior conditioned fear design human subject indexing insight male neuroimaging pre-clinical reinforcer response reward circuitry social visual process visual processing

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four pa.qes) ..................... 12 Other Biographical Sketches (Not to exceed four pages for each - See instructions)) ............................ 15 Resources ........................................................................................................................................................ 42 Research Plan Introduction to Revised Application (Notto exceed 3 pages) ................................................................................................................ Introduction to Supplemental Application (Not to exceed one page) ..................................................................................................... 48 A. Specific Aims ............................................................................ ._. ......................................................................................... 48 B. Background and Significance ................................................... .....|. ........................................................................................ I 57 C, Preliminary Studies/Progress Report/ _ (Items A-D: not to exceed 25 pages*) "_t Phase I Progress Report (SBIR/STTR Phase II ONLY) F SBIR/STTR Phase l: ltems A-D limited t¿15 pages I [3. Research Design and Methods ................................................ _ .......................................................................................... 62 E. Human Subjects .......................................................................................................................................................................... 73 Protection of Human Subjects (Required if Item 4 on the Face Page is marked "Yes") Inclusion of Women (Required if Item 4 on the Face Page is marked "Yes") ...................................................................... Inclusion of Minorities (Required if Item 4 on the Face Page is marked "Yes") .................................................................... Inclusion of Children (Required if Item 4 on the Face Page is marked "Yes") ...................................................................... Data and Safety Monitoring Plan (Required if Item 4 on the Face Page is marked "Yes" anda Phase I, II, or III clinical trial is proposed ............................................................................................................................................................... F. Vertebrate Animals ...................................................................................................................................................................... G. Literature Cited ............................................................................................................................................................................ 82 H. Consortium/Contractual Arrangements ....................................................................................................................................... I. Letters of Support (e.g., Consultants) ......................................................................................................................................... 96 J. Product Development Plan (SBIRISTTR Phase II and Fast-Track ONLY) ............................................................................... Checklist ........................................................................................................................................................... 102 Check if Appendix (Five collated sets. No page numbering necessary for Appendix.) Appendix is Included Appendices NO T PERMITTED for Phase I SBIR/S TTR unless specifically solicited. Number of publications and manuscdpts accepted for publication (not to exceed 10) Other items (list): Appendix I Color Plates of Figures in Preliminary Studies PHS 398 (Rev. 05/01) Page 3 Form Page 3

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