DAKO ACIS II Image Analysis System for the University of South Carolina

南卡罗来纳大学的 DAKO ACIS II 图像分析系统

• 批准号: 7215064
• 负责人: Robert L Price
• 金额: $ 17.89万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7215064
• 关键词: American Cancer Society; Area; Cancer Center; Cardiovascular system; Cellular biology; Colon Carcinoma; Core Facility; Data; Development; Disease; Ensure; Environment; Funding; Grant; Histology; Housing; Image Analysis; Immunohistochemistry; Laboratories; Malignant Neoplasms; Minor; Neurosciences; North America; Numbers; Operative Surgical Procedures; Productivity; Purpose; Request for Proposals; Research; Research Personnel; Resources; Sampling; South Carolina; Staining method; Stains; Standardization; Standards of Weights and Measures; System; Travel; United States National Institutes of Health; Universities; anticancer research; cellular imaging; day; instrument; instrumentation; medical schools

DESCRIPTION (provided by applicant): DAKO Chromavision ACIS II Image Analysis System This proposal requests $175,850 to purchase a DAKO ACIS II image analysis system that will be housed in the Instrumentation Resource Facility (IRF) of the University of South Carolina School of Medicine and South Carolina Cancer Center (SCCC). Major users of the system will be 13 NIH funded researchers associated with the School of Medicine, the SCCC and the University of South Carolina Center for Colon Cancer Research (CCCR). Two other minor users of the system are young investigators that have American Cancer Society and/or NIH funding. The system will be used in a variety of research areas including cardiovascular development and disease, neurosciences and cancer. Collectively, the Users group holds 22 NIH grants. The DAKO ACIS II cell imaging system was selected as the instrument of choice after obtaining demonstrations on available systems at several meetings including FASEB, Cell Biology and the American Cancer Society meetings. In addition, Ms. Valerie Kennedy, the technologist who will be responsible for the day-to-day operation of the system, has traveled to the offices of DAKO North America, Inc. in Carpinteria, CA to analyze several samples relevant to the research of the Major Users. The purpose of this trip was to ensure the ACIS II system is capable of performing the image analysis tasks needed by our research group. The primary purpose for acquiring the system will be to automate our analyses of a number of standard immunohistochemistry (IHC) stains that are performed within the laboratories of the investigators participating in this proposal. This will significantly increase the acquisition and standardization of data from a variety of IHC stains produced for these investigators by the Histology Core in the IRF. Examples of the detailed analyses the ACIS II is capable of and how the automated features of the system will enhance the research productivity and competitiveness of each investigator is presented below in the Research Descriptions provided by the Major Users in this proposal. Acquisition of this system and housing it in an established core facility will allow access to it by a large number of investigators and will significantly enhance the research environment at the University of South Carolina.

描述（由申请人提供）：DAKO Chromavision ACIS II图像分析系统本提案要求175，850美元购买DAKO ACIS II图像分析系统，该系统将被安置在南卡罗来纳州医学院和南卡罗来纳州癌症中心（SCCC）的仪器资源设施（IRF）中。该系统的主要用户将是13名NIH资助的研究人员，他们与医学院、SCCC和南卡罗来纳州大学结肠癌研究中心（CCCR）有关。该系统的另外两个小用户是拥有美国癌症协会和/或NIH资助的年轻研究人员。该系统将用于各种研究领域，包括心血管发育和疾病，神经科学和癌症。总的来说，用户组拥有22个NIH赠款。在FASEB、细胞生物学和美国癌症协会会议等多个会议上获得可用系统的演示后，DAKO ACIS II细胞成像系统被选为首选仪器。此外，负责系统日常操作的技术专家Valerie Kennedy女士已前往DAKO North America，Inc.的办公室。在Carpinteria，CA分析与主要用户研究相关的几个样本。此行的目的是确保ACIS II系统能够执行我们研究小组所需的图像分析任务。获取该系统的主要目的是使我们对参与本提案的研究者实验室内进行的许多标准免疫组织化学（IHC）染色的分析自动化。这将显著增加IRF组织学核心为这些研究者提供的各种IHC染色数据的采集和标准化。货物预报信息系统II所能进行的详细分析以及该系统的自动化特点将如何提高每个调查人员的研究生产力和竞争力的例子，见本建议书中主要用户提供的研究说明。购买该系统并将其安置在一个已建立的核心设施中，将允许大量调查人员使用该系统，并将大大改善南卡罗来纳州大学的研究环境。