IVIS Spectrum Imaging System for the University of South Carolina

南卡罗来纳大学 IVIS 光谱成像系统

• 批准号: 7792159
• 负责人: Robert L Price
• 金额: $ 38.15万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-01 至 2011-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7792159
• 关键词: American Cancer Society; American Heart Association; Animals; Area; Arts; Autoimmune Process; Bioluminescence; Biomedical Research; Biophotonics; Biotechnology; Cardiovascular Diseases; Cell physiology; Center Core Grants; Centers of Research Excellence; Colon Carcinoma; Communities; Development; Disease; Fluorescence; Funding; Genetic; Grant; Housing; Image; Inflammatory; Inflammatory Response; Institution; Life; Malignant Neoplasms; Medicine; Modeling; Monitor; Mus; Pathway interactions; Pharmaceutical Preparations; Pharmacy facility; Price; Public Health; Rattus; Request for Proposals; Research; Research Personnel; Resources; Science; Scientist; South Carolina; System; Technology; Time; Translational Research; Treatment Protocols; Universities; anticancer research; college; in vivo; instrument; instrumentation; medical schools; meetings; programs; public health relevance; response; tool

DESCRIPTION (provided by applicant): This proposal requests $381,491 for the purchase of a Caliper LifeSciences IVIS Spectrum in vivo imaging system for the University of South Carolina. The IVIS Spectrum is a state-of-the-art instrument that will meet the in vivo fluorescence and bioluminescence imaging needs of the University of South Carolina biomedical research community for the next several years. The system will enable in vivo biophotonic imaging for the purpose of non-invasively and longitudinally monitoring disease processes, cellular responses and genetic pathways in mouse and rat models used by all of the investigators on this proposal. There are no in vivo imaging systems for fluorescence and bioluminescence imaging at the University of South Carolina. Investigators on this proposal are ten well funded scientists representative of the larger biomedical research community at the University of South Carolina that will benefit from acquisition of the IVIS Spectrum in vivo imaging system. As a group the investigators are Principle Investigators of a P20 Center for Colon Cancer Research COBRE, a P01 Center for CAM Research on Autoimmune and Inflammatory Diseases, 11 R01 grants, an American Heart Association Scientist Development grant, and an American Cancer Society Research Scholar Grant. They are also a mix of senior and junior investigators that represent the Colleges of Arts and Sciences, Public Health, Pharmacy, and Medicine. In addition, Drs. Price and Pena are PIs of Cores for Center grants that interact with a large number of investigators around the state of South Carolina and this technology will be made available to all investigators involved with these biomedical research programs. The system will be housed in the Instrumentation Resource Facility of the University Of South Carolina School Of Medicine. The IRF is an established core biotechnology facility serving the University of South Carolina as well as several other undergraduate and graduate institutions in the State of South Carolina. PUBLIC HEALTH RELEVANCE: Non-invasive imaging of living animals over time has become an important research tool in monitoring the progression of a number of diseases including cancer, inflammatory responses, and cardiovascular disease. The IVIS Spectrum fluorescence and bioluminescence technology requested in this proposal will be an important tool for biomedical researchers at the University of South Carolina in their efforts to develop translational research programs in these areas as well as in development of new drugs and treatment regimens.

描述(由申请人提供)：该提案申请381,491美元，用于为南卡罗来纳大学购买卡利珀生命科学IVIS光谱活体成像系统。IVIS光谱是一种最先进的仪器，将满足南卡罗来纳大学生物医学研究界未来几年的活体荧光和生物发光成像需求。该系统将实现体内生物光子成像，目的是非侵入性和纵向监测疾病过程、细胞反应和遗传路径，所有研究人员都在这项提议中使用小鼠和大鼠模型。南卡罗来纳大学没有用于荧光和生物发光成像的活体成像系统。这项提议的调查人员是10名资金雄厚的科学家，他们代表着南卡罗来纳大学更大的生物医学研究社区，他们将从收购IVIS Spectrum in vivo成像系统中受益。作为一个小组，研究人员是P20结肠癌研究中心、P01自身免疫和炎症性疾病CAM研究中心、11个R01资助、美国心脏协会科学家发展资助和美国癌症协会研究学者资助的首席研究员。他们也是代表文理学院、公共卫生学院、药房学院和医学院的高级和初级调查人员的混合体。此外，普莱斯博士和佩纳博士是与南卡罗来纳州各地的大量研究人员互动的中心拨款核心的PI，这项技术将向参与这些生物医学研究项目的所有研究人员提供。该系统将存放在南卡罗来纳大学医学院的仪器资源设施中。研究所是南卡罗来纳大学以及南卡罗来纳州其他几个本科生和研究生机构的既定核心生物技术机构。 公共卫生相关性：随着时间的推移，活体动物的非侵入性成像已成为监测包括癌症、炎症反应和心血管疾病在内的许多疾病进展的重要研究工具。建议中要求的IVIS光谱荧光和生物发光技术将成为南卡罗来纳大学生物医学研究人员努力开发这些领域的转化研究计划以及开发新药和治疗方案的重要工具。