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Marine and Freshwater Biomedical Sciences Center

海洋和淡水生物医学科学中心

基本信息

批准号：
7036581
负责人：
David E Williams
金额：
$ 42.26万
依托单位：
OREGON STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-04-01 至 2007-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7036581
关键词：
aquatic biology chemical carcinogen clinical research environment related neoplasm /cancer fresh water environment saltwater environment

项目摘要

The Marine and Freshwater Biomedical Sciences Center (MFBSC) uses aquatic species as models of human disease. The MFBSC consists of 6 Cores - 2 Research, 2 Facilities and Services, a Community Outreach, and a Pilot Project and Program Enrichment Core. The 2 Research Cores are supported by extramural grants and OSU, and no research funds or salary are requested. The Director utilizes Internal and Extemal Advisory Committees for guidance on scientific and administrative issues. The MFBSC provides facilities and training for scientists using aquatic models in biomedical research. Training (two NIEHS Training Grants) at the graduate, undergraduate, and postdoctoral levels are important goals of the MFBSC as is education and outreach (also supported by an NIEHS grant) to multiple community groups, including K-12 educators and the general public. The Center maintains its strengths in carcinogenesis, cancer chemoprevention, neurotoxicology and marine natural products. Addition of new faculty expands the focus into developmental toxicology and toxicogenomics. Successful synergism is evidenced by joint grants and publications. A new effort in toxicogenomics provides evidence of synergism among MFBS Centers. The MFBSC makes possible the pursuit of studies of environmental health important regionally, nationally and internationally. Important contributions in the last funding period include: 1) A successful clinical trial in China (directed by the NIEHS Center at Johns Hopkins with G. Bailey as Co-I) of a cancer chemopreventive agent first identified in the trout tumor model; 2) Completion of the largest cancer study in any animal model, that lowered the limit of detection of tumor incidence by more than an order of magnitude and tested the conservative linear model for risk extrapolation; 3) Development of a mobi(e fish cell biosensor of neurotoxins, including nerve gas agents; and 4) Discovery of several extremely potent neurotoxins from marine cyanobacteria that give new insights into the structure and function of the mammalian voltage-gated sodium channel, and may have therapeutic uses. Our goal over the next 5-year funding period is to build on these accomplishments by employing new approaches and technologies to pursue studies on the impacts of environmental chemicals on human health and conveying that information effectively to the public.

海洋和淡水生物医学科学中心（MFBSC）使用水生物种作为人类疾病的模型。MFBSC由6个核心组成- 2个研究，2个设施和服务，一个社区外展，以及一个试点项目和计划充实核心。2研究核心由校外赠款和OSU支持，不要求研究资金或工资。主任利用内部和外部咨询委员会就科学和行政问题提供指导。MFBSC为在生物医学研究中使用水生模型的科学家提供设施和培训。研究生、本科生和博士后水平的培训（两项NIEHS培训赠款）是MFBSC的重要目标，教育和推广（也得到NIEHS赠款的支持）也是如此。包括K-12教育工作者和公众。中心在致癌作用、癌症化学预防、神经毒理学和海洋天然产物方面保持优势。新教师的加入将重点扩大到发育毒理学和毒理基因组学。联合赠款和出版物证明了成功的协同作用。毒理基因组学的一项新努力提供了MFBS中心之间协同作用的证据。 MFBSC使得有可能追求环境健康的研究重要的区域，国家和国际。在上一个资助期内的重要贡献包括：1）在中国成功进行的临床试验（由约翰霍普金斯NIEHS中心指导，G. Bailey作为Co-I）首次在鳟鱼肿瘤模型中鉴定出的癌症化学预防剂; 2）完成了在任何动物模型中最大的癌症研究，将肿瘤发病率的检测限降低了一个数量级以上，并测试了保守的线性模型用于风险外推; 3）开发了移动鱼细胞生物传感器 4）从海洋蓝细菌中发现了几种极强的神经毒素，使人们对哺乳动物电压门控钠通道的结构和功能有了新的认识，并可能具有治疗用途。我们下一个五年资助期的目标是在这些成就的基础上，采用新的方法和技术，继续研究环境化学品对人类健康的影响，并有效地向公众传达这一信息。

项目成果

期刊论文数量（185）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The distribution, elimination, and in vivo biotransformation of aldicarb in the rainbow trout (Oncorhynchus mykiss).

涕灭威在虹鳟鱼 (Oncorhynchus mykiss) 中的分布、消除和体内生物转化。

DOI：
10.1016/0272-0590(92)90205-v
发表时间：
1992
期刊：
Fundamental and applied toxicology : official journal of the Society of Toxicology
影响因子：
0
作者：
Schlenk,D;Erickson,DA;Lech,JJ;Buhler,DR
通讯作者：
Buhler,DR

Alterations in lipid peroxidation, antioxidant enzymes, and carcinogen metabolism in liver microsomes of vitamin E-deficient trout and rat.

缺乏维生素 E 的鳟鱼和大鼠肝微粒体中脂质过氧化、抗氧化酶和致癌物代谢的变化。