LASER SCANNING CYTOMETRY FOR T-CELL SUBSETS IN MACAQUES

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: This project evaluates laser scanning cytometry (LSC) to analyze both viral gene expression (measured by in situ hybridization) and changes in leukocyte populations (measured by cellular immunophenotype) in macaques infected with simian-human immunodeficiency virus (SHIV). Accordingly, this method will help define the cellular mechanism(s) that accounts for simian AIDS in newborns.