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PROTEOMICS ANALYSIS OF SCHISTOSOME HOST-INVASION AND METABOLISM

PROTEOMICS ANALYSIS OF SCHISTOSOME HOST-INVASION AND METABOLISM
血吸虫宿主入侵和代谢的蛋白质组学分析
批准号:
7369081
负责人:
James H. McKerrow
金额:
$2.04万
依托单位国家:
美国
项目类别:
财政年份:
2006
资助国家:
美国
项目状态:
已结题
起止时间:
2006-03-01 至 2007-02-28

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英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In these experiments, we are attempting to identify the natural substrates for the protease of invasive schistosome larvae in skin. Schistosome cercariae are incubated with sections of human skin and products of degradation extracted. Initial gel analysis reveals major protein bands suitable for identification by mass spectrometry. These studies are ongoing.
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Evaluation of a cathepsin S inhibitor as a potential drug for Chagas disease
HYDROLYSIS OF HEMOGLOBIN BY SCHISTSOMA MANSONI CATHEPSIN B-LIKE CYSTEINEPROTEASE
STRUCTURE BASED DRUG DESIGN FOR TREATMENT OF PARASITIC AND VIRAL DISEASES
GIARDIA LAMBLIA CYSTEINE PROTEASES: TRAFFICKING, LOCALIZATION, AND FUNCTION
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