PROTEOMICS ANALYSIS OF SCHISTOSOME HOST-INVASION AND METABOLISM

血吸虫宿主入侵和代谢的蛋白质组学分析

• 批准号: 7369081
• 负责人: James H. McKerrow
• 金额: $ 2.04万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7369081
• 关键词: PROTEOMICS; ANALYSIS; SCHISTOSOME; HOST; INVASION

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In these experiments, we are attempting to identify the natural substrates for the protease of invasive schistosome larvae in skin. Schistosome cercariae are incubated with sections of human skin and products of degradation extracted. Initial gel analysis reveals major protein bands suitable for identification by mass spectrometry. These studies are ongoing.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。在这些实验中，我们试图确定侵袭性血吸虫幼虫在皮肤中的蛋白酶的天然底物。血吸虫尾蚴与人体皮肤切片和提取的降解产物一起孵化。初步凝胶分析显示，主要的蛋白质条带适合通过质谱学进行鉴定。这些研究正在进行中。