Harnessing the Innate Immune System to Target Cancer: A Novel Immunotherapeutic Strategy for Solid Tumours

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Despite recent improvements in cancer treatments, cancer remains a major cause of death world-wide. This project builds on our recent research demonstrating a novel mechanism by which to 'kick-start' the patient's own immune system to mount an effective anti-cancer response. Specifically we seek to utilise C3aR-targeting antisense oligonucleotides developed by our commercial partner for treatment of advanced cancers that are unresponsive to current immunotherapeutic approaches.