ALTERATION OF SYMPATHETIC ACT & BP BY CPAP IN SLEEP APNEA PATIENTS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to determine whether sleep deprivation causes an increase in activity of the nervous system such that heart rate and blood pressure are elevated. The study will also assess the responses of the nervous system, heart rate and blood pressure after sleep deprivation. Prior studies have shown that patients with sleep apnea have a predisposition to developing hypertension. It is possible that the development of hypertension is due to the elevated sympathetic nerve activity which these individuals have been shown to possess. The sleep deprivation resulting from the sleep apnea may be a causal actor in the elevated sympathetic nerve activity and play a role in the development of the hypertension.