EFFECTS OF INHIBITORS OF METABOLIC VASODILATION DURING HYPOXIA

缺氧期间代谢性血管舒张抑制剂的作用

• 批准号: 7951239
• 负责人: URS A LEUENBERGER
• 金额: $ 0.6万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951239
• 关键词: Adenosine; Aminophylline; Blood flow; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Exposure to; Funding; Grant; Hypoxia; Institution; Ketorolac; Limb structure; Metabolic; Nitric Oxide; Nitric Oxide Synthase; Pathway interactions; Prostaglandins; Protocols documentation; Purinergic P1 Receptors; Research; Research Personnel; Resources; Source; Testing; United States National Institutes of Health; Vasodilation; inhibitor/antagonist; omega-N-Methylarginine

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this protocol, the investigators will test the isolated and combined effects of regional blockade of adenosine (with the adenosine-receptor inhibitor aminophylline), nitric oxide (with nitric oxide synthase inhibitor NG-monomethyl-L-arginine, L-NMMA) and prostaglandin (with prostaglandin synthesis inhibitor ketorolac) pathways on limb blood flow during exposure to systemic hypoxia.

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