EFFECTS OF INHIBITORS OF METABOLIC VASODILATION DURING HYPOXIA

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 在本方案中，研究者将检测暴露于全身性缺氧期间腺苷（使用腺苷受体抑制剂氨茶碱）、一氧化氮（使用一氧化氮合酶抑制剂NG-单甲基-L-精氨酸，L-NMMA）和前列腺素（使用前列腺素合成抑制剂酮咯酸）通路局部阻断对肢体血流的单独和联合作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this protocol, the investigators will test the isolated and combined effects of regional blockade of adenosine (with the adenosine-receptor inhibitor aminophylline), nitric oxide (with nitric oxide synthase inhibitor NG-monomethyl-L-arginine, L-NMMA) and prostaglandin (with prostaglandin synthesis inhibitor ketorolac) pathways on limb blood flow during exposure to systemic hypoxia.